metfo-xr
Generic Name
Metformin Hydrochloride Extended-Release
Manufacturer
Square Pharmaceuticals PLC.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| metfo xr 500 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Metfo-XR 500 mg Tablet is an oral antidiabetic medicine used to control high blood sugar levels in people with type 2 diabetes mellitus, especially in overweight patients. It is typically used in conjunction with diet and exercise.
Uses & Indications
Dosage
Adults
Initial dose: 500 mg once daily with the evening meal. Dose may be increased by 500 mg weekly to a maximum of 2000 mg once daily. Swallow whole, do not crush or chew.
Elderly
Start with a low dose and monitor renal function regularly due to potential for decreased renal function.
Renal_impairment
Contraindicated if eGFR <30 mL/min/1.73m². Dose adjustment required if eGFR 30-45 mL/min/1.73m².
How to Take
Take orally, once daily with the evening meal. Swallow the tablet whole; do not crush, chew, or break it.
Mechanism of Action
Metformin reduces hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
Pharmacokinetics
Onset
Gradual onset, full therapeutic effect may take several days.
Excretion
Excreted unchanged in the urine.
Half life
Plasma elimination half-life is approximately 6.2 hours.
Absorption
Slow and incomplete from the gastrointestinal tract for XR formulation. Bioavailability is approximately 50-60%.
Metabolism
Not metabolized in the liver.
Side Effects
Contraindications
- •Severe renal impairment (eGFR <30 mL/min/1.73m²)
- •Acute or chronic metabolic acidosis, including diabetic ketoacidosis
- •Hypersensitivity to metformin hydrochloride
- •Dehydration, severe infection, shock, severe heart failure, acute myocardial infarction, respiratory failure, hepatic insufficiency, acute alcohol intoxication, alcoholism.
Drug Interactions
Alcohol
Potentiates the effect of metformin on lactate metabolism, increasing the risk of lactic acidosis.
Cimetidine
May increase metformin plasma concentrations, increasing risk of lactic acidosis.
Iodinated contrast agents
Temporarily discontinue metformin at the time of or prior to an iodinated contrast imaging procedure and for 48 hours afterward in patients with an eGFR between 30 and 60 mL/min/1.73m².
Carbonic Anhydrase Inhibitors (e.g., Topiramate, Zonisamide)
May increase the risk of lactic acidosis.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose of metformin may lead to lactic acidosis, characterized by dyspnea, abdominal pain, hypothermia, and coma. Management involves supportive care and immediate hemodialysis to remove lactate and metformin.
Pregnancy & Lactation
Pregnancy Category B. Limited data suggest it is unlikely to cause adverse effects during pregnancy, but insulin is often preferred for glycemic control. Small amounts of metformin are excreted in breast milk; consult a doctor before breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
