Metform-ER
Generic Name
Metformin Hydrochloride (Extended Release) 1000 mg Tablet
Manufacturer
Various Manufacturers (Generic)
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| metform er 1000 mg tablet | ৳ 9.00 | ৳ 72.00 |
Description
Overview of the medicine
Metformin Extended Release 1000 mg tablet is an oral antidiabetic medication used to control blood sugar levels in people with Type 2 Diabetes Mellitus.
Uses & Indications
Dosage
Adults
Initial dose is typically 500 mg or 750 mg once daily with the evening meal. Dose may be gradually increased by 500 mg weekly to a maximum of 2000 mg once daily. For 1000 mg, it is usually taken once daily with the evening meal.
Elderly
Dose adjustment based on renal function is crucial due to potential age-related decline in kidney function. Start with a lower dose.
Renal_impairment
Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73 m²). Dose adjustment required for moderate impairment; discontinue if eGFR drops below 30.
How to Take
Take with food, usually with the evening meal, to minimize gastrointestinal side effects. Swallow the tablet whole; do not crush, chew, or break it.
Mechanism of Action
It works by decreasing glucose production by the liver, decreasing intestinal absorption of glucose, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization.
Pharmacokinetics
Onset
Gradual (due to extended-release formulation).
Excretion
Excreted unchanged in the urine by the kidneys.
Half life
Approximately 4-9 hours (plasma elimination half-life).
Absorption
Slow and incomplete from the gastrointestinal tract, increased with food. Bioavailability is approximately 50-60%.
Metabolism
Metformin is not metabolized in the liver.
Side Effects
Contraindications
- •Severe renal impairment (eGFR <30 mL/min/1.73 m²)
- •Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma
- •Hypersensitivity to metformin hydrochloride or any component of the formulation
Drug Interactions
Alcohol
Potentiates the effect of metformin on lactate metabolism, increasing the risk of lactic acidosis.
Cimetidine
Increases metformin plasma concentrations by reducing renal tubular secretion.
Iodinated Contrast Agents
Temporarily discontinue metformin at the time of or prior to iodinated contrast imaging procedures and restart 48 hours later, if renal function is stable, to avoid lactic acidosis.
Diuretics (e.g., Thiazides)
May increase blood glucose levels, potentially requiring metformin dose adjustment.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose can lead to lactic acidosis, which requires immediate medical attention. Management involves supportive care and measures to correct acidosis, such as hemodialysis to remove metformin.
Pregnancy & Lactation
Consult a doctor before use during pregnancy or lactation. Insulin is generally preferred for managing diabetes in pregnant women. Metformin is excreted into breast milk; risks/benefits should be discussed.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the date of manufacture, specific to manufacturer.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic available (Patent expired)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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