Metform-ER
Generic Name
Metformin Extended-Release 500 mg Tablet
Manufacturer
Various (Generic)
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| metform er 500 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
An oral antidiabetic medicine used to manage type 2 diabetes mellitus, particularly in overweight individuals, when diet and exercise alone are not enough.
Uses & Indications
Dosage
Adults
Initial dose is usually 500 mg once daily with the evening meal. May be increased by 500 mg weekly up to a maximum of 2000 mg once daily.
Elderly
Dosage should be individualized based on renal function, starting with lower doses to minimize risk of lactic acidosis.
Renal_impairment
Contraindicated in severe renal impairment (eGFR < 30 mL/min/1.73m²). Dose adjustment required for moderate impairment (eGFR 30-60 mL/min/1.73m²).
How to Take
Take orally once daily with the evening meal. Swallow whole, do not crush, chew, or break the tablet to maintain its extended-release properties.
Mechanism of Action
Decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
Pharmacokinetics
Onset
Gradual, full effect seen over several days to weeks.
Excretion
Excreted unchanged in the urine by glomerular filtration and tubular secretion.
Half life
Approximately 6.2 hours for immediate release; extended release kinetics vary and may have an effective half-life up to 17 hours.
Absorption
Oral bioavailability is 50-60%. Food delays and slightly decreases the extent of absorption. Extended-release formulation maintains plasma concentrations for longer.
Metabolism
Not metabolized in the liver.
Side Effects
Contraindications
- •Severe renal impairment (eGFR < 30 mL/min/1.73m²)
- •Acute or chronic metabolic acidosis (including diabetic ketoacidosis)
- •Hypersensitivity to metformin
- •Acute heart failure
- •Severe infection
- •Hepatic impairment
- •Dehydration
Drug Interactions
Alcohol
Potentiates the effect of metformin on lactate metabolism, increasing the risk of lactic acidosis.
Cimetidine
Increases metformin plasma concentration, potentially increasing risk of lactic acidosis.
Iodinated Contrast Media
Temporarily discontinue metformin before or at the time of an iodinated contrast imaging procedure and for 48 hours afterward. Re-evaluate renal function before restarting.
Carbonic Anhydrase Inhibitors (e.g., topiramate)
May increase risk of lactic acidosis.
Certain Antihypertensives (e.g., ACE inhibitors, ARBs)
Can alter renal function, potentially affecting metformin elimination.
Storage
Store below 30°C (86°F) in a dry place, away from direct light and moisture. Keep out of reach and sight of children.
Overdose
Overdose may lead to lactic acidosis, which is a medical emergency. Management includes hemodialysis for rapid metformin removal and intensive supportive care. Symptoms include malaise, myalgia, respiratory distress, and abdominal pain.
Pregnancy & Lactation
Pregnancy category B. Consult doctor. Small amounts may pass into breast milk; generally considered compatible with breastfeeding, but caution is advised and monitor infant for hypoglycemia.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, depending on the manufacturer and specific formulation.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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