Methasol-N
Generic Name
Mometasone Furoate + Fusidic Acid
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| methasol n 01 05 eye drop | ৳ 35.11 | N/A |
| methasol n 01 05 eye ointment | ৳ 14.00 | N/A |
Description
Overview of the medicine
Methasol-N Cream is a combination medication containing Mometasone Furoate, a corticosteroid, and Fusidic Acid, an antibiotic. It is used to treat inflammatory skin conditions such as eczema and dermatitis that are either infected or likely to become infected with bacteria.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected skin area twice daily for up to two weeks.
Elderly
No specific dose adjustment required, use with caution.
Renal_impairment
Not expected to require dose adjustment due to minimal systemic absorption.
How to Take
For external use only. Apply a thin film to the affected skin area and gently rub in. Wash hands before and after application.
Mechanism of Action
Mometasone Furoate is a potent corticosteroid that works by decreasing the release of substances in the body that cause inflammation, swelling, and itching. Fusidic Acid is an antibacterial agent that inhibits bacterial protein synthesis by interfering with the translocation step, leading to bacteriostatic or bactericidal effects against susceptible organisms, particularly Staphylococcus aureus.
Pharmacokinetics
Onset
Onset of action for symptomatic relief usually within a few days.
Excretion
Mometasone Furoate is excreted via bile and urine. Fusidic Acid metabolites are primarily excreted in the bile.
Half life
Systemic half-life for Mometasone is approximately 5.8 hours. For Fusidic Acid, it is approximately 5-6 hours after systemic absorption.
Absorption
Mometasone Furoate has minimal systemic absorption when applied topically. Fusidic Acid also shows limited systemic absorption through intact skin but can be absorbed through damaged skin.
Metabolism
Mometasone Furoate is primarily metabolized in the liver. Fusidic Acid is extensively metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to mometasone furoate, fusidic acid, or any component of the formulation.
- Viral infections (e.g., herpes simplex, varicella), fungal infections, tuberculosis of the skin, acne vulgaris, rosacea, perioral dermatitis.
Drug Interactions
0
No significant topical drug interactions are reported for mometasone furoate or fusidic acid when used as directed.
1
Avoid prolonged use on large areas with other topical corticosteroids.
Storage
Store below 30°C. Do not freeze. Keep out of the reach of children.
Overdose
Topical overdose is unlikely to cause acute systemic problems. Prolonged or excessive use of corticosteroids may lead to systemic effects such as Cushing's syndrome, adrenal suppression. Management involves gradual withdrawal of the drug and supportive therapy.
Pregnancy & Lactation
Use with caution during pregnancy and lactation only if the potential benefit outweighs the potential risk. Avoid prolonged use or application to large areas.
Side Effects
Contraindications
- Hypersensitivity to mometasone furoate, fusidic acid, or any component of the formulation.
- Viral infections (e.g., herpes simplex, varicella), fungal infections, tuberculosis of the skin, acne vulgaris, rosacea, perioral dermatitis.
Drug Interactions
0
No significant topical drug interactions are reported for mometasone furoate or fusidic acid when used as directed.
1
Avoid prolonged use on large areas with other topical corticosteroids.
Storage
Store below 30°C. Do not freeze. Keep out of the reach of children.
Overdose
Topical overdose is unlikely to cause acute systemic problems. Prolonged or excessive use of corticosteroids may lead to systemic effects such as Cushing's syndrome, adrenal suppression. Management involves gradual withdrawal of the drug and supportive therapy.
Pregnancy & Lactation
Use with caution during pregnancy and lactation only if the potential benefit outweighs the potential risk. Avoid prolonged use or application to large areas.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of Mometasone Furoate and Fusidic Acid combination in treating inflammatory dermatoses with secondary bacterial infections.
Lab Monitoring
- No routine lab monitoring is required for topical use. For prolonged or extensive use, monitoring for adrenal axis suppression may be considered.
- Monitor for signs of secondary infection.
Doctor Notes
- Advise patients to limit treatment duration to two weeks.
- Emphasize not to use on face, groin, or axillae unless specifically directed.
- Be aware of potential for systemic corticosteroid effects with extensive use.
Patient Guidelines
- Do not use for more than 2 weeks without consulting a doctor.
- Avoid contact with eyes.
- Do not apply on broken skin or mucous membranes.
- Do not cover the treated area with occlusive dressings unless advised by a doctor.
Missed Dose Advice
Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not apply extra cream to make up for a missed dose.
Driving Precautions
No known effects on ability to drive or operate machinery for topical application.
Lifestyle Advice
- Keep the affected skin clean and dry.
- Avoid irritants and allergens that may worsen your skin condition.
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Global Brand Names
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