Metherspan
Generic Name
Methylprednisolone
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| metherspan 125 mcg tablet | ৳ 0.55 | ৳ 5.50 |
| metherspan 200 mcg injection | ৳ 3.00 | N/A |
Description
Overview of the medicine
Metherspan (Methylprednisolone) is a corticosteroid used to treat a wide range of inflammatory and autoimmune conditions, including asthma, allergic reactions, arthritis, and certain skin conditions.
Uses & Indications
Dosage
Adults
Initial dose varies from 4 mg to 48 mg daily, depending on the specific disease being treated. Dosage should be individualized based on patient response and tolerance.
Elderly
Lower doses may be required due to increased sensitivity to side effects and potential comorbidities. Dosage should be carefully titrated.
Renal_impairment
No specific dosage adjustment is generally needed for patients with renal impairment, but caution is advised in severe cases.
How to Take
Take Metherspan tablets orally with food or milk to minimize gastrointestinal upset. Do not chew or crush the tablet. Swallow whole with water. Do not stop taking this medicine abruptly without consulting your doctor, as it may lead to withdrawal symptoms.
Mechanism of Action
Methylprednisolone works by reducing inflammation and suppressing the immune system. It inhibits the release of substances in the body that cause inflammation.
Pharmacokinetics
Onset
Anti-inflammatory effects typically begin within 1 hour after oral administration.
Excretion
Excreted mainly in the urine as inactive metabolites.
Half life
Biological half-life is approximately 18-36 hours, meaning effects can last for a day or longer.
Absorption
Well absorbed orally, with peak plasma concentrations occurring 1-2 hours after administration.
Metabolism
Primarily metabolized in the liver by the CYP3A4 enzyme, converting it to inactive metabolites.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
- Administration of live or live attenuated vaccines during corticosteroid therapy
Drug Interactions
Warfarin
Effects on anticoagulant therapy may vary; monitor INR.
Antidiabetic agents
Methylprednisolone may increase blood glucose levels, requiring adjustment of antidiabetic drug dosage.
Diuretics (e.g., furosemide)
Increased potassium loss and risk of hypokalemia.
Non-steroidal anti-inflammatory drugs (NSAIDs)
Increased risk of gastrointestinal bleeding and ulceration.
CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
May increase plasma concentrations of methylprednisolone.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose with methylprednisolone is rare but may lead to symptoms such as fluid retention, hypertension, hyperglycemia, and psychiatric disturbances. Management is primarily supportive and symptomatic. Gastric lavage or activated charcoal may be considered in severe cases.
Pregnancy & Lactation
Metherspan should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk, so caution should be exercised when administered to a nursing woman. Consult your doctor.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
- Administration of live or live attenuated vaccines during corticosteroid therapy
Drug Interactions
Warfarin
Effects on anticoagulant therapy may vary; monitor INR.
Antidiabetic agents
Methylprednisolone may increase blood glucose levels, requiring adjustment of antidiabetic drug dosage.
Diuretics (e.g., furosemide)
Increased potassium loss and risk of hypokalemia.
Non-steroidal anti-inflammatory drugs (NSAIDs)
Increased risk of gastrointestinal bleeding and ulceration.
CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
May increase plasma concentrations of methylprednisolone.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose with methylprednisolone is rare but may lead to symptoms such as fluid retention, hypertension, hyperglycemia, and psychiatric disturbances. Management is primarily supportive and symptomatic. Gastric lavage or activated charcoal may be considered in severe cases.
Pregnancy & Lactation
Metherspan should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk, so caution should be exercised when administered to a nursing woman. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Methylprednisolone has been extensively studied in numerous clinical trials demonstrating its efficacy and safety across a wide range of inflammatory, allergic, and autoimmune conditions. Ongoing research continues to explore new applications and optimal dosing strategies.
Lab Monitoring
- Blood glucose levels (especially in diabetic patients)
- Blood pressure monitoring
- Electrolyte levels (particularly potassium)
- Bone mineral density (for long-term therapy)
- Ophthalmic exams (for long-term therapy)
Doctor Notes
- Emphasize the importance of gradual tapering to prevent adrenal insufficiency upon discontinuation.
- Monitor patients for signs of infection, especially those on immunosuppressive doses.
- Advise patients on dietary modifications (e.g., calcium, vitamin D supplementation, low sodium) for long-term therapy.
Patient Guidelines
- Do not stop taking Metherspan suddenly; always consult your doctor for gradual tapering.
- Report any signs of infection (fever, sore throat) immediately, as corticosteroids can mask symptoms.
- Avoid close contact with people who have infectious diseases (e.g., chickenpox, measles) while on this medication.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Metherspan may cause dizziness, blurred vision, or muscle weakness in some individuals. If you experience these effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to support bone health.
- Limit sodium intake to help manage fluid retention and blood pressure.
- Engage in regular, moderate exercise to maintain muscle strength and overall well-being.
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Global Brand Names
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