Methipred
Generic Name
Methylprednisolone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| methipred 4 mg tablet | ৳ 5.75 | ৳ 86.20 |
Description
Overview of the medicine
Methipred 4 mg Tablet contains Methylprednisolone, a synthetic corticosteroid used to treat various inflammatory and autoimmune conditions. It works by reducing inflammation and suppressing the immune system.
Uses & Indications
Dosage
Adults
Initial dosage varies from 4 mg to 48 mg daily, depending on the specific disease being treated. For chronic conditions, maintenance dose should be kept at the lowest effective level.
Elderly
Use with caution, lowest effective dose. Increased risk of side effects.
Renal_impairment
Generally no dose adjustment needed for renal impairment, but caution with fluid retention.
How to Take
Oral. Should be taken with food or milk to minimize gastrointestinal irritation.
Mechanism of Action
Methylprednisolone works by binding to intracellular glucocorticoid receptors. This complex then translocates to the nucleus and modulates gene expression, leading to anti-inflammatory and immunosuppressive effects. It inhibits the release of inflammatory mediators like prostaglandins and leukotrienes.
Pharmacokinetics
Onset
Hours to days, depending on condition and dosage.
Excretion
Excreted mainly in the urine as inactive metabolites.
Half life
Biological half-life is 18-36 hours; plasma half-life is 2-3 hours.
Absorption
Well absorbed orally. Peak plasma concentrations are reached in 1-2 hours.
Metabolism
Primarily metabolized in the liver by CYP3A4 enzymes.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
- Administration of live or live-attenuated vaccines (when immunosuppressive doses are used)
Drug Interactions
Warfarin
Methylprednisolone can either potentiate or inhibit the anticoagulant effect of warfarin; monitor INR.
Diuretics (Thiazide or Loop)
May enhance potassium depletion.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal ulceration and bleeding.
CYP3A4 inhibitors (e.g., Ketoconazole, Erythromycin)
May decrease methylprednisolone clearance, leading to increased effects.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include Cushingoid features, muscle weakness, and hypertension. Management is supportive and symptomatic; gradual withdrawal is necessary after prolonged high-dose therapy.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Methylprednisolone is excreted in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
- Administration of live or live-attenuated vaccines (when immunosuppressive doses are used)
Drug Interactions
Warfarin
Methylprednisolone can either potentiate or inhibit the anticoagulant effect of warfarin; monitor INR.
Diuretics (Thiazide or Loop)
May enhance potassium depletion.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal ulceration and bleeding.
CYP3A4 inhibitors (e.g., Ketoconazole, Erythromycin)
May decrease methylprednisolone clearance, leading to increased effects.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include Cushingoid features, muscle weakness, and hypertension. Management is supportive and symptomatic; gradual withdrawal is necessary after prolonged high-dose therapy.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Methylprednisolone is excreted in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, patent expired for the molecule
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of methylprednisolone in various inflammatory and autoimmune conditions. Ongoing research continues to explore new applications and optimal dosing strategies.
Lab Monitoring
- Blood pressure
- Blood glucose
- Electrolytes (especially potassium)
- Bone mineral density (for long-term use)
- Growth in children
- Ophthalmic exams (for long-term use)
Doctor Notes
- Emphasize gradual tapering, especially after prolonged therapy, to prevent adrenal crisis.
- Monitor patients for signs of infection, blood glucose, blood pressure, and bone health during long-term treatment.
- Advise patients on potential mood changes and gastric irritation.
Patient Guidelines
- Do not stop taking this medicine abruptly without consulting your doctor, especially after prolonged use.
- Take with food or milk to reduce stomach upset.
- Inform your doctor about all medications you are taking.
- Report any unusual side effects immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not double dose.
Driving Precautions
Methylprednisolone may cause dizziness or visual disturbances in some patients. If these symptoms occur, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a diet rich in calcium and vitamin D to support bone health.
- Limit sodium intake to manage fluid retention.
- Engage in regular, moderate exercise if possible.
- Avoid exposure to infections, especially during immunosuppressive therapy.
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