Methipred
Generic Name
Methylprednisolone
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| methipred 500 mg injection | ৳ 600.00 | N/A |
Description
Overview of the medicine
Methipred 500 mg Injection contains Methylprednisolone, a synthetic glucocorticoid with potent anti-inflammatory and immunosuppressive properties. It is used to treat a wide range of inflammatory and autoimmune conditions.
Uses & Indications
Dosage
Adults
Dosage varies greatly depending on the condition being treated. For pulse therapy, typically 500-1000 mg IV daily for 3-5 days. For acute severe conditions, initial doses can range from 10-500 mg, repeated as needed. Always follow physician's instruction.
Elderly
No specific dose adjustment for elderly patients is generally required, but close monitoring for adverse effects is recommended due to potential age-related decline in organ function.
Renal_impairment
No specific dose adjustment is generally required for renal impairment, as methylprednisolone is primarily metabolized by the liver.
How to Take
Methipred 500 mg Injection is administered intravenously (IV) or intramuscularly (IM). For IV administration, it is usually given slowly over several minutes to an hour, depending on the dose. It must be prepared by a healthcare professional.
Mechanism of Action
Methylprednisolone works by binding to intracellular glucocorticoid receptors, leading to altered gene expression. This results in the inhibition of inflammatory mediators (e.g., prostaglandins, leukotrienes, cytokines) and suppression of immune responses.
Pharmacokinetics
Onset
Rapid, typically within minutes for IV administration.
Excretion
Mainly excreted in urine as inactive metabolites.
Half life
Plasma half-life is approximately 2-3 hours; biological half-life is 18-36 hours.
Absorption
Rapidly and extensively absorbed after intravenous (IV) or intramuscular (IM) administration.
Metabolism
Primarily metabolized in the liver by the CYP3A4 enzyme.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
- Administration of live or live attenuated vaccines when immunosuppressed
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration and bleeding.
Antidiabetic agents
May increase blood glucose levels, requiring dose adjustment of antidiabetic drugs.
Potassium-depleting diuretics
Increased risk of hypokalemia.
Anticoagulants (e.g., Warfarin)
May potentiate or inhibit anticoagulant effects; monitor INR.
CYP3A4 inducers (e.g., Rifampicin, Phenytoin)
May decrease methylprednisolone levels.
CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir)
May increase methylprednisolone levels.
Storage
Store intact vials at controlled room temperature (20°C to 25°C), protected from light. Do not freeze. Reconstituted solution should be used promptly or stored as per manufacturer's instructions.
Overdose
Acute overdose with methylprednisolone is rare and usually does not cause life-threatening consequences. Symptoms may include fluid retention, hypertension, hyperglycemia, and aggravation of known side effects. Chronic overdose can lead to Cushingoid features and adrenal suppression. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Methylprednisolone is excreted in human milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
- Administration of live or live attenuated vaccines when immunosuppressed
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration and bleeding.
Antidiabetic agents
May increase blood glucose levels, requiring dose adjustment of antidiabetic drugs.
Potassium-depleting diuretics
Increased risk of hypokalemia.
Anticoagulants (e.g., Warfarin)
May potentiate or inhibit anticoagulant effects; monitor INR.
CYP3A4 inducers (e.g., Rifampicin, Phenytoin)
May decrease methylprednisolone levels.
CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir)
May increase methylprednisolone levels.
Storage
Store intact vials at controlled room temperature (20°C to 25°C), protected from light. Do not freeze. Reconstituted solution should be used promptly or stored as per manufacturer's instructions.
Overdose
Acute overdose with methylprednisolone is rare and usually does not cause life-threatening consequences. Symptoms may include fluid retention, hypertension, hyperglycemia, and aggravation of known side effects. Chronic overdose can lead to Cushingoid features and adrenal suppression. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Methylprednisolone is excreted in human milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 2-3 years, as indicated on the packaging. Reconstituted solution typically stable for 48 hours at room temperature.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by major regulatory bodies worldwide including DGDA (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Methylprednisolone has undergone extensive clinical trials since its introduction, supporting its efficacy and safety across numerous indications. Ongoing research continues to explore its role in various conditions and optimize dosing strategies.
Lab Monitoring
- Blood glucose levels (especially in diabetics)
- Electrolytes (e.g., potassium)
- Blood pressure monitoring
- Bone mineral density (for long-term use)
- Adrenal function (if discontinuing after long-term therapy)
Doctor Notes
- Emphasize the importance of patient education regarding gradual withdrawal to prevent adrenal crisis.
- Monitor blood glucose, electrolytes, and blood pressure regularly.
- Assess for signs of infection, especially in immunosuppressed patients.
- Consider bone protection strategies (e.g., calcium/vitamin D) for long-term therapy.
Patient Guidelines
- Do not stop this medicine abruptly; it must be tapered off under medical supervision.
- Report any signs of infection, fever, or unusual bruising/bleeding to your doctor immediately.
- Inform your doctor about all other medicines, supplements, and herbal products you are taking.
- Avoid contact with people who have infections (e.g., chickenpox, measles) if you are on immunosuppressive doses.
Missed Dose Advice
If a scheduled dose is missed, contact your doctor or healthcare provider immediately for advice. Do not double the dose to compensate for a missed one.
Driving Precautions
Methylprednisolone may cause dizziness, blurred vision, or mood changes in some patients. If these symptoms occur, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to support bone health.
- Engage in regular, moderate exercise if medically appropriate.
- Limit sodium intake to manage fluid retention and blood pressure.
- Avoid alcohol and smoking.
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