Metro
Generic Name
Metronidazole 500 mg Injection
Manufacturer
Generic Pharmaceutical Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| metro 500 mg injection | ৳ 85.50 | N/A |
Description
Overview of the medicine
Metronidazole is a nitroimidazole antibiotic used to treat various bacterial and parasitic infections. It is effective against anaerobic bacteria and certain protozoa.
Uses & Indications
Dosage
Adults
Usually 500 mg intravenously every 8 hours, infused slowly over 30-60 minutes. Dosage varies based on indication and severity.
Elderly
No specific dose adjustment for elderly patients with normal renal and hepatic function, but caution is advised due to potential decreased liver function.
Renal_impairment
Dose adjustment may be necessary in severe renal impairment (CrCl <10 mL/min). A reduction by 50% for patients undergoing hemodialysis is often recommended, administered after dialysis.
How to Take
Administer intravenously by slow infusion over a period of 30-60 minutes. Do not administer as a rapid bolus injection. Always check for compatibility if mixing with other solutions.
Mechanism of Action
Metronidazole is a prodrug. After entering anaerobic cells, it is reduced to active metabolites that interact with DNA, causing strand breakage and inhibition of nucleic acid synthesis, leading to cell death.
Pharmacokinetics
Onset
Rapid onset of action after intravenous infusion.
Excretion
Mainly renal (60-80% as parent drug and metabolites); some fecal excretion (6-15%).
Half life
Approximately 6-8 hours.
Absorption
Rapid and complete absorption after intravenous administration.
Metabolism
Primarily hepatic, via oxidation and glucuronidation.
Side Effects
Contraindications
- •Hypersensitivity to metronidazole or other nitroimidazole derivatives.
- •First trimester of pregnancy (relative contraindication, use only if essential).
Drug Interactions
Alcohol
Disulfiram-like reaction (abdominal cramps, nausea, vomiting, headaches, flushing). Avoid alcohol during and for at least 3 days after treatment.
Lithium
May increase serum lithium levels, leading to lithium toxicity.
Warfarin
Increases anticoagulant effect, leading to increased risk of bleeding. Monitor INR closely.
Cimetidine
May prolong metronidazole half-life and decrease its clearance.
Phenytoin/Phenobarbital
May reduce metronidazole plasma levels.
Storage
Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, ataxia, seizures, and peripheral neuropathy. Management is supportive and symptomatic; there is no specific antidote.
Pregnancy & Lactation
Avoid during the first trimester of pregnancy; use in later trimesters only if clearly needed. Metronidazole is excreted into breast milk; breastfeeding should be temporarily discontinued during treatment and for 12-24 hours after the last dose.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, specific to manufacturer's guidelines.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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