Metsina
Generic Name
Metronidazole 200 mg Suspension
Manufacturer
MediCare Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| metsina 200 mg suspension | ৳ 35.00 | N/A |
Description
Overview of the medicine
Metsina 200 mg Suspension is an antibiotic medication primarily used to treat various bacterial and parasitic infections. It belongs to the nitroimidazole class of antibiotics and works by stopping the growth of certain bacteria and parasites.
Uses & Indications
Dosage
Adults
Typically, 400 mg three times daily for 5-10 days for amoebiasis; 200-400 mg three times daily for 5-7 days for other infections. For suspension, dosage adjusted by volume.
Elderly
No specific dosage adjustment for elderly with normal renal and hepatic function. Use with caution due to potential for reduced hepatic metabolism.
Renal_impairment
Dose reduction may be necessary in severe renal impairment (CrCl <10 mL/min). Administer 50% of the usual dose every 12-24 hours. No adjustment needed for mild to moderate impairment.
How to Take
Metsina Suspension should be taken orally, usually with food or milk to minimize gastrointestinal upset. Shake the bottle well before each use. Use the provided measuring cup or spoon to ensure accurate dosage.
Mechanism of Action
Metronidazole is a nitroimidazole derivative that acts as a prodrug. It is selectively taken up by anaerobic bacteria and sensitive protozoa. Once inside, the nitro group of metronidazole is reduced by electron transport proteins to a highly reactive nitro radical. These radicals damage DNA and other vital biomolecules, leading to cell death.
Pharmacokinetics
Onset
Therapeutic effects usually observed within 24-48 hours, depending on the infection type.
Excretion
Mainly via urine (60-80% as metabolites and unchanged drug), some via feces (6-15%).
Half life
Approximately 8 hours (range 6-12 hours).
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract (about 80% within 1 hour).
Metabolism
Extensively metabolized in the liver, primarily by oxidation, to hydroxyl and other acidic metabolites.
Side Effects
Contraindications
- Hypersensitivity to metronidazole or other nitroimidazole derivatives.
- First trimester of pregnancy (relative contraindication, generally avoided).
- Concurrent use of alcohol or disulfiram.
Drug Interactions
Alcohol
Disulfiram-like reaction (abdominal cramps, nausea, vomiting, headaches, flushing) can occur due to inhibition of alcohol dehydrogenase.
Lithium
May increase serum lithium levels, leading to lithium toxicity. Monitor lithium levels.
Warfarin
May enhance the anticoagulant effect of warfarin and other oral anticoagulants, leading to increased risk of bleeding. Monitor INR closely.
Disulfiram
Concomitant use can lead to psychotic reactions; avoid co-administration.
Phenobarbital/Phenytoin
May decrease metronidazole plasma levels by inducing hepatic enzymes.
Storage
Store below 30°C, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, ataxia, and mild disorientation. There is no specific antidote. Management involves symptomatic and supportive treatment. Gastric lavage may be considered if ingestion is recent.
Pregnancy & Lactation
Category B for pregnancy, but generally avoided in the first trimester. Use with caution in later trimesters only if clearly needed. Metronidazole is excreted into breast milk; consider temporary discontinuation of breastfeeding or alternative treatment during therapy.
Side Effects
Contraindications
- Hypersensitivity to metronidazole or other nitroimidazole derivatives.
- First trimester of pregnancy (relative contraindication, generally avoided).
- Concurrent use of alcohol or disulfiram.
Drug Interactions
Alcohol
Disulfiram-like reaction (abdominal cramps, nausea, vomiting, headaches, flushing) can occur due to inhibition of alcohol dehydrogenase.
Lithium
May increase serum lithium levels, leading to lithium toxicity. Monitor lithium levels.
Warfarin
May enhance the anticoagulant effect of warfarin and other oral anticoagulants, leading to increased risk of bleeding. Monitor INR closely.
Disulfiram
Concomitant use can lead to psychotic reactions; avoid co-administration.
Phenobarbital/Phenytoin
May decrease metronidazole plasma levels by inducing hepatic enzymes.
Storage
Store below 30°C, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, ataxia, and mild disorientation. There is no specific antidote. Management involves symptomatic and supportive treatment. Gastric lavage may be considered if ingestion is recent.
Pregnancy & Lactation
Category B for pregnancy, but generally avoided in the first trimester. Use with caution in later trimesters only if clearly needed. Metronidazole is excreted into breast milk; consider temporary discontinuation of breastfeeding or alternative treatment during therapy.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Metronidazole has been extensively studied since its introduction. Numerous clinical trials have confirmed its efficacy in treating various anaerobic bacterial and protozoal infections, including amoebiasis, giardiasis, and trichomoniasis, with established safety profiles.
Lab Monitoring
- Liver function tests (especially in patients with hepatic impairment)
- Complete blood count (for prolonged therapy to monitor for neutropenia)
- INR (for patients on warfarin)
Doctor Notes
- Educate patients on alcohol avoidance during and post-treatment.
- Monitor for neurological adverse effects, especially with prolonged use.
- Adjust dose in severe hepatic or renal impairment.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve.
- Avoid alcohol during and for 3 days after treatment.
- Take with food or milk to reduce stomach upset.
- Report any severe side effects, especially neurological symptoms.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Metsina may cause dizziness, confusion, or visual disturbances. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea.
- Follow a balanced diet.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Metsina Brand
Other medicines available under the same brand name
