Metsina
Generic Name
Metronidazole
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| metsina 400 mg tablet | ৳ 1.70 | ৳ 17.00 |
Description
Overview of the medicine
Metsina 400 mg Tablet contains Metronidazole, an antibiotic and antiprotozoal medicine used to treat various bacterial and parasitic infections.
Uses & Indications
Dosage
Adults
For amoebiasis: 400 mg three times daily for 5-10 days. For giardiasis: 400 mg three times daily for 5-7 days. For anaerobic infections: 400 mg three times daily, duration depends on infection. Always follow physician's advice.
Elderly
No specific dose adjustment is generally required, but caution is advised in patients with hepatic impairment.
Renal_impairment
No dosage adjustment necessary for mild to moderate renal impairment. For severe renal impairment, dose reduction may be considered.
How to Take
Take orally with or after food to minimize gastrointestinal upset. Swallow the tablet whole with water, do not chew or crush.
Mechanism of Action
Metronidazole is a nitroimidazole antimicrobial that enters the bacterial or protozoal cell, where it is reduced by electron transport proteins to reactive cytotoxic compounds. These compounds damage DNA and other biomolecules, leading to cell death.
Pharmacokinetics
Onset
Varies by infection type, typically within hours for symptomatic relief.
Excretion
Mainly renal (60-80% as metabolites and unchanged drug), with some fecal excretion (6-15%).
Half life
Approximately 6-12 hours in healthy adults.
Absorption
Rapidly and almost completely absorbed after oral administration. Peak plasma concentrations usually occur within 1-2 hours.
Metabolism
Primarily hepatic, largely by oxidation with side-chain cleavage and glucuronide conjugation. Major metabolite (2-hydroxymethylmetronidazole) also has antibacterial and antiprotozoal activity.
Side Effects
Contraindications
- Hypersensitivity to metronidazole or other nitroimidazole derivatives
- First trimester of pregnancy (unless essential)
- Active neurological disease
Drug Interactions
Alcohol
Disulfiram-like reaction, avoid alcohol during treatment and for at least 3 days after.
Lithium
May increase lithium levels, monitor.
Warfarin
May potentiate anticoagulant effect, adjust warfarin dose.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, ataxia, and mild disorientation. Treatment is symptomatic and supportive; there is no specific antidote.
Pregnancy & Lactation
Use during pregnancy, especially the first trimester, only if clearly needed and potential benefits outweigh risks. Metronidazole is excreted into breast milk; consider temporary cessation of breastfeeding or pump and discard milk during treatment.
Side Effects
Contraindications
- Hypersensitivity to metronidazole or other nitroimidazole derivatives
- First trimester of pregnancy (unless essential)
- Active neurological disease
Drug Interactions
Alcohol
Disulfiram-like reaction, avoid alcohol during treatment and for at least 3 days after.
Lithium
May increase lithium levels, monitor.
Warfarin
May potentiate anticoagulant effect, adjust warfarin dose.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, ataxia, and mild disorientation. Treatment is symptomatic and supportive; there is no specific antidote.
Pregnancy & Lactation
Use during pregnancy, especially the first trimester, only if clearly needed and potential benefits outweigh risks. Metronidazole is excreted into breast milk; consider temporary cessation of breastfeeding or pump and discard milk during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by health authorities worldwide
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of metronidazole for its approved indications.
Lab Monitoring
- Complete Blood Count (CBC) for prolonged therapy
- Liver function tests (LFTs) in patients with hepatic impairment
- Renal function tests if dosage adjustment considered
Doctor Notes
- Advise patients to avoid alcohol completely during and for 72 hours post-treatment.
- Monitor for neurological adverse effects, especially with prolonged use.
- Consider dose adjustment in severe hepatic impairment.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve.
- Avoid alcohol during treatment and for at least 3 days after.
- Report any unusual or severe side effects to your doctor.
- Do not drive or operate machinery if you experience dizziness or confusion.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or confusion in some individuals. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Stay hydrated by drinking plenty of fluids.
- Follow a balanced diet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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