Mexilyt
Generic Name
Mexilyt
Manufacturer
Local Pharma Inc.
Country
Bangladesh (Assumed for local context)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mexilyt 4 mg syrup | ৳ 18.06 | N/A |
Description
Overview of the medicine
Mexilyt (Mexiletine) is an antiarrhythmic agent used to treat documented life-threatening ventricular arrhythmias, such as sustained ventricular tachycardia.
Uses & Indications
Dosage
Adults
Initial: 200 mg orally every 8 hours. Dosage may be adjusted in 50-100 mg increments every 2-3 days based on response and tolerance. Max 1200 mg/day.
Elderly
Lower initial doses (e.g., 100-150 mg every 8 hours) may be considered due to potential reduced hepatic metabolism and renal clearance. Careful monitoring is advised.
Renal_impairment
No significant dosage adjustment for mild to moderate impairment, but careful monitoring is advised. Severe impairment (CrCl <10 mL/min) may require a 30-50% dose reduction.
How to Take
Taken orally with food or milk to minimize gastrointestinal upset. Swallow capsules whole; do not crush or chew.
Mechanism of Action
Mexilyt (Mexiletine) is a Class IB antiarrhythmic that acts by blocking voltage-gated sodium channels in myocardial cells, thereby inhibiting the rapid influx of sodium ions and stabilizing the cardiac cell membrane. This reduces the rate of spontaneous depolarization and conduction velocity.
Pharmacokinetics
Onset
30 minutes to 2 hours
Excretion
Renal (10% unchanged, rest as metabolites). Urinary acidification increases excretion.
Half life
10-12 hours (can vary with pH and liver function)
Absorption
Well absorbed orally, bioavailability 80-90%. Peak plasma concentrations achieved in 2-3 hours.
Metabolism
Primarily hepatic (CYP2D6, CYP1A2) with extensive first-pass metabolism.
Side Effects
Contraindications
- •Cardiogenic shock
- •Second- or third-degree AV block in the absence of a pacemaker
- •Pre-existing severe sinus node dysfunction in the absence of a pacemaker
Drug Interactions
Theophylline
Mexiletine may increase theophylline levels, requiring dose adjustment of theophylline.
Beta-blockers
Concurrent use may exacerbate cardiac depression and bradycardia; monitor carefully.
Phenytoin/Rifampin
Strong CYP2D6 and CYP1A2 inducers may significantly decrease mexiletine plasma concentrations.
Antacids/Cimetidine
May increase mexiletine plasma concentrations by affecting its absorption or metabolism.
Storage
Store at controlled room temperature (20-25°C or 68-77°F). Protect from moisture, heat, and direct light. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose include severe central nervous system effects (e.g., seizures, confusion, coma), severe cardiovascular effects (e.g., hypotension, bradycardia, cardiac arrest), and nausea/vomiting. Management involves symptomatic and supportive care, including gastric lavage, activated charcoal, vasopressors for hypotension, and anti-seizure medication (e.g., diazepam).
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Mexilyt is excreted in breast milk; therefore, caution is advised during lactation, and the decision to discontinue nursing or the drug should be made considering the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date, refer to packaging for exact date.
Availability
Hospital and retail pharmacies
Approval Status
FDA Approved
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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