Micatel
Generic Name
Telmisartan
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| micatel 20 mg tablet | ৳ 7.00 | ৳ 49.00 |
Description
Overview of the medicine
Telmisartan is an angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension) and to reduce the risk of cardiovascular events such as heart attack or stroke in high-risk patients.
Uses & Indications
Dosage
Adults
For hypertension: Initial dose 40 mg once daily. Dosage may be increased to a maximum of 80 mg once daily after 4-8 weeks if needed. For cardiovascular risk reduction: 80 mg once daily.
Elderly
No dose adjustment generally required based on age, but close monitoring for adverse effects is recommended.
Renal_impairment
No dose adjustment is required for patients with mild to moderate renal impairment. For severe impairment, caution and monitoring are advised.
How to Take
Take orally, once daily, with or without food. Swallow the tablet whole with water. It should be taken at approximately the same time each day.
Mechanism of Action
Telmisartan selectively blocks the binding of angiotensin II to the AT1 receptor, which is found in many tissues, including vascular smooth muscle and the adrenal gland. This inhibition leads to vasodilation, reduction in aldosterone secretion, and overall decreased blood pressure.
Pharmacokinetics
Onset
Within 3 hours, peak effect achieved within 4-8 weeks of therapy.
Excretion
Primarily excreted unchanged in feces via biliary excretion (>97%). A small amount is excreted in urine.
Half life
Approximately 24 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract. Absolute bioavailability is approximately 42% for a 40 mg dose and 58% for a 20 mg dose.
Metabolism
Metabolized by conjugation to form an acylglucuronide, which is pharmacologically inactive.
Side Effects
Contraindications
- Hypersensitivity to telmisartan or any component of the formulation.
- Pregnancy (especially second and third trimesters).
- Lactation.
- Biliary obstructive disorders.
- Severe hepatic impairment.
Drug Interactions
Digoxin
Concomitant use may increase plasma digoxin concentrations.
Lithium
Concurrent use may increase serum lithium concentrations and lead to lithium toxicity.
Diuretics (e.g., Hydrochlorothiazide)
May increase the hypotensive effect, leading to symptomatic hypotension.
NSAIDs (e.g., Ibuprofen, Indomethacin)
May reduce the antihypertensive effect of telmisartan and increase the risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited data on overdose in humans. The most likely manifestations would be hypotension and tachycardia; bradycardia could also occur. Treatment is symptomatic and supportive. Telmisartan is not removed by hemodialysis.
Pregnancy & Lactation
Contraindicated during pregnancy, especially during the second and third trimesters, due to risks of fetal injury and death. Not recommended during lactation as telmisartan is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to telmisartan or any component of the formulation.
- Pregnancy (especially second and third trimesters).
- Lactation.
- Biliary obstructive disorders.
- Severe hepatic impairment.
Drug Interactions
Digoxin
Concomitant use may increase plasma digoxin concentrations.
Lithium
Concurrent use may increase serum lithium concentrations and lead to lithium toxicity.
Diuretics (e.g., Hydrochlorothiazide)
May increase the hypotensive effect, leading to symptomatic hypotension.
NSAIDs (e.g., Ibuprofen, Indomethacin)
May reduce the antihypertensive effect of telmisartan and increase the risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited data on overdose in humans. The most likely manifestations would be hypotension and tachycardia; bradycardia could also occur. Treatment is symptomatic and supportive. Telmisartan is not removed by hemodialysis.
Pregnancy & Lactation
Contraindicated during pregnancy, especially during the second and third trimesters, due to risks of fetal injury and death. Not recommended during lactation as telmisartan is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Expired
Clinical Trials
Telmisartan has been extensively studied in various clinical trials, including the ONTARGET and TRANSCEND studies, which demonstrated its efficacy in reducing cardiovascular events in high-risk patients.
Lab Monitoring
- Blood pressure (regularly)
- Renal function (serum creatinine, BUN)
- Serum potassium levels (especially in patients with renal impairment or on potassium-sparing diuretics)
Doctor Notes
- Monitor blood pressure, renal function, and serum potassium levels periodically.
- Caution advised when co-administering with NSAIDs, lithium, or digoxin.
- Emphasize strict adherence to prescribed dosage and lifestyle modifications for optimal therapeutic outcomes.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking Micatel without consulting your doctor, even if you feel well.
- Inform your doctor about all other medications you are taking.
- Report any unusual side effects promptly to your healthcare provider.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Micatel may cause dizziness or drowsiness, especially at the start of treatment or when the dose is increased. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Adopt a healthy lifestyle including a balanced diet low in sodium.
- Engage in regular physical activity as advised by your doctor.
- Avoid smoking and limit alcohol consumption to help manage blood pressure.
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