Micatel
Generic Name
Telmisartan
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| micatel 40 mg tablet | ৳ 13.00 | ৳ 91.00 |
Description
Overview of the medicine
Micatel 40 mg tablet contains Telmisartan, an angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension) and to reduce the risk of cardiovascular events in certain high-risk patients.
Uses & Indications
Dosage
Adults
Initial dose 40 mg once daily. Max dose 80 mg once daily.
Elderly
No specific dose adjustment is necessary, but a lower starting dose may be considered.
Renal_impairment
No dose adjustment required for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Oral administration. May be taken with or without food, once daily.
Mechanism of Action
Telmisartan selectively blocks the binding of angiotensin II to the AT1 receptor in various tissues, including vascular smooth muscle and the adrenal gland. This inhibits the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to vasodilation and decreased blood pressure.
Pharmacokinetics
Onset
Antihypertensive activity within 3 hours. Full effect in 4-8 weeks.
Excretion
Primarily excreted unchanged via feces (over 97%). Minor renal excretion.
Half life
Approximately 24 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with absolute bioavailability of about 42-58%. Food intake has a minor effect on absorption.
Metabolism
Minimally metabolized to an inactive acylglucuronide. Not metabolized by cytochrome P450 system.
Side Effects
Contraindications
- Hypersensitivity to Telmisartan or any component of the formulation
- Pregnancy (especially second and third trimesters)
- Lactation
- Biliary obstructive disorders
- Severe hepatic impairment
- Concomitant use with aliskiren in patients with diabetes or renal impairment
Drug Interactions
Digoxin
Increased plasma digoxin concentrations.
Lithium
Increased serum lithium concentrations and toxicity.
Aliskiren
Contraindicated in diabetes or renal impairment; increased risk of hyperkalemia, hypotension, and renal impairment.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal impairment.
Potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium
May lead to hyperkalemia.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms may include hypotension, dizziness, tachycardia, or bradycardia. Treatment is symptomatic and supportive; hemodialysis is unlikely to be effective. Closely monitor vital signs.
Pregnancy & Lactation
Contraindicated during pregnancy, especially during the second and third trimesters, due to risk of fetal harm. Not recommended during lactation due to potential adverse effects on the nursing infant.
Side Effects
Contraindications
- Hypersensitivity to Telmisartan or any component of the formulation
- Pregnancy (especially second and third trimesters)
- Lactation
- Biliary obstructive disorders
- Severe hepatic impairment
- Concomitant use with aliskiren in patients with diabetes or renal impairment
Drug Interactions
Digoxin
Increased plasma digoxin concentrations.
Lithium
Increased serum lithium concentrations and toxicity.
Aliskiren
Contraindicated in diabetes or renal impairment; increased risk of hyperkalemia, hypotension, and renal impairment.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal impairment.
Potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium
May lead to hyperkalemia.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms may include hypotension, dizziness, tachycardia, or bradycardia. Treatment is symptomatic and supportive; hemodialysis is unlikely to be effective. Closely monitor vital signs.
Pregnancy & Lactation
Contraindicated during pregnancy, especially during the second and third trimesters, due to risk of fetal harm. Not recommended during lactation due to potential adverse effects on the nursing infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available (Patent expired for Telmisartan)
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials like ONTARGET (Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) and TRANSCEND (Telmisartan Randomised Assessment Study in ACE intolerant subjects with cardiovascular Disease).
Lab Monitoring
- Serum electrolytes (especially potassium)
- Renal function tests (creatinine, BUN)
- Blood pressure monitoring
Doctor Notes
- Regularly monitor blood pressure, renal function, and serum potassium levels.
- Counsel patients on the importance of adherence and lifestyle modifications.
- Avoid in pregnant women and those planning pregnancy.
Patient Guidelines
- Take this medicine consistently at the same time each day.
- Do not stop taking it without consulting your doctor, even if you feel well.
- Report any symptoms like dizziness, fainting, or swelling immediately.
- Avoid potassium supplements or salt substitutes unless advised by your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or lightheadedness, especially when initiating treatment or increasing dose. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Adopt a low-sodium diet.
- Engage in regular physical activity.
- Maintain a healthy weight.
- Limit alcohol consumption.
- Quit smoking.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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