Microgest
Generic Name
Progesterone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| microgest 100 mg capsule | ৳ 16.00 | ৳ 160.00 |
Description
Overview of the medicine
Microgest 100 mg Capsule contains micronized Progesterone, a naturally occurring steroid hormone that plays a key role in the menstrual cycle and maintenance of early pregnancy. It is used in hormone replacement therapy and for various gynecological conditions.
Uses & Indications
Dosage
Adults
Luteal support: 200-400 mg daily, Secondary amenorrhea: 400 mg daily for 10 days, HRT: 200 mg daily for 12-14 days sequentially or 100 mg daily continuously.
Elderly
Similar to adult dosage, with caution in hepatic/renal impairment.
Renal_impairment
Use with caution; dosage adjustment may be necessary in severe impairment.
How to Take
Oral administration. Take the capsule with water, preferably at bedtime to minimize dizziness/drowsiness. May be taken with food to improve absorption.
Mechanism of Action
Progesterone is a natural progestogen that binds to intracellular progesterone receptors, leading to gene expression changes. It induces secretory changes in the endometrium, maintains pregnancy, and inhibits uterine contractions. It also has anti-estrogenic effects.
Pharmacokinetics
Onset
Variable; effects on endometrium seen within hours to days.
Excretion
Primarily via urine as metabolites, with some fecal excretion.
Half life
Approximately 5-20 hours (variable due to metabolites).
Absorption
Readily absorbed after oral administration, subject to extensive first-pass metabolism. Absorption can be enhanced by micronization.
Metabolism
Primarily hepatic, extensive first-pass metabolism, forming various metabolites (e.g., pregnanediol, pregnanolone).
Side Effects
Contraindications
- Known hypersensitivity to Progesterone or any component
- Undiagnosed vaginal bleeding
- Known or suspected breast cancer or other hormone-sensitive cancers
- Active thrombophlebitis or thromboembolic disorders
- Severe liver dysfunction
- Missed abortion
Drug Interactions
Barbiturates
May reduce the effect of progesterone.
CYP3A4 inhibitors (e.g., Ketoconazole, Erythromycin)
May increase progesterone levels, potentially increasing side effects.
CYP3A4 inducers (e.g., Rifampicin, Carbamazepine, Phenytoin)
May decrease progesterone levels, reducing efficacy.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, nausea, and fatigue. Treatment is symptomatic and supportive. No specific antidote.
Pregnancy & Lactation
Progesterone is often used to support early pregnancy and prevent miscarriage under medical supervision. It is excreted in breast milk; caution is advised during lactation, and use only if clearly needed and benefits outweigh risks.
Side Effects
Contraindications
- Known hypersensitivity to Progesterone or any component
- Undiagnosed vaginal bleeding
- Known or suspected breast cancer or other hormone-sensitive cancers
- Active thrombophlebitis or thromboembolic disorders
- Severe liver dysfunction
- Missed abortion
Drug Interactions
Barbiturates
May reduce the effect of progesterone.
CYP3A4 inhibitors (e.g., Ketoconazole, Erythromycin)
May increase progesterone levels, potentially increasing side effects.
CYP3A4 inducers (e.g., Rifampicin, Carbamazepine, Phenytoin)
May decrease progesterone levels, reducing efficacy.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, nausea, and fatigue. Treatment is symptomatic and supportive. No specific antidote.
Pregnancy & Lactation
Progesterone is often used to support early pregnancy and prevent miscarriage under medical supervision. It is excreted in breast milk; caution is advised during lactation, and use only if clearly needed and benefits outweigh risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available (patent expired for generic progesterone)
WHO Essential Medicine
YesClinical Trials
Extensively studied for its role in reproductive medicine and HRT. Ongoing trials explore new indications and formulations.
Lab Monitoring
- Liver function tests (periodically)
- Blood pressure
- Lipid profiles (for long-term HRT)
- Blood glucose (in diabetic patients)
Doctor Notes
- Monitor patients for signs of thromboembolic disorders.
- Regular gynecological check-ups are advised during prolonged therapy.
- Caution in patients with a history of depression as progesterone can exacerbate mood changes.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking suddenly without consulting your doctor.
- Report any unusual bleeding or severe side effects immediately.
- Avoid driving or operating machinery if experiencing dizziness or drowsiness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness. Patients should be warned not to drive or operate machinery until the effects are known.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid smoking and excessive alcohol consumption, especially during HRT.
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