Microgest
Generic Name
Progesterone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| microgest 400 mg vaginal pessary | ৳ 50.00 | N/A |
Description
Overview of the medicine
Progesterone is a female hormone important for the regulation of ovulation and menstruation. Microgest 400 mg vaginal pessary is used in fertility treatments, for maintaining pregnancy, and preventing preterm birth. The vaginal route allows direct delivery to the uterus.
Uses & Indications
Dosage
Adults
Typically 400 mg once or twice daily, vaginally. Dosing starts from the day of embryo transfer or as advised by the physician. Duration depends on the indication and physician's guidance.
Elderly
No specific dose adjustment is generally required, but caution is advised in elderly patients with hepatic or renal impairment.
Renal_impairment
Use with caution; no specific dose adjustment guidelines, but monitoring is advised if severe impairment.
How to Take
Insert the pessary deep into the vagina, preferably at bedtime. Wash hands thoroughly before and after use.
Mechanism of Action
Progesterone acts by binding to progesterone receptors in the uterus, vagina, and other tissues. It converts the proliferative endometrium into a secretory one, which is essential for successful implantation and maintenance of pregnancy. It also inhibits uterine contractions.
Pharmacokinetics
Onset
Systemic effects can be observed within hours, local uterine effects are more direct and rapid.
Excretion
Mainly renal, as glucuronide and sulfate conjugates.
Half life
Approximately 16-18 hours (for progesterone generally, depends on route and formulation).
Absorption
Rapidly absorbed from the vaginal mucosa, leading to high local concentrations in the uterus and systemic circulation.
Metabolism
Primarily hepatic, converted to pregnanediol and other metabolites.
Side Effects
Contraindications
- Undiagnosed vaginal bleeding.
- Known or suspected breast cancer or other hormone-sensitive cancers.
- Active arterial thromboembolic disease or severe thrombophlebitis.
- Severe liver dysfunction.
- Porphyria.
Drug Interactions
Phenytoin
May decrease progesterone levels through enzyme induction.
Rifampicin
May decrease progesterone levels due to hepatic enzyme induction.
Ketoconazole
May increase progesterone levels by inhibiting its metabolism.
Carbamazepine
May decrease progesterone levels by enhancing its metabolism.
Storage
Store below 30°C in a dry place, protected from direct light and moisture. Keep out of reach of children.
Overdose
Overdose is unlikely with vaginal administration. Symptoms may include drowsiness, dizziness, or short-lived mood changes. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Used to support early pregnancy and prevent preterm birth. Not recommended during lactation as progesterone can pass into breast milk.
Side Effects
Contraindications
- Undiagnosed vaginal bleeding.
- Known or suspected breast cancer or other hormone-sensitive cancers.
- Active arterial thromboembolic disease or severe thrombophlebitis.
- Severe liver dysfunction.
- Porphyria.
Drug Interactions
Phenytoin
May decrease progesterone levels through enzyme induction.
Rifampicin
May decrease progesterone levels due to hepatic enzyme induction.
Ketoconazole
May increase progesterone levels by inhibiting its metabolism.
Carbamazepine
May decrease progesterone levels by enhancing its metabolism.
Storage
Store below 30°C in a dry place, protected from direct light and moisture. Keep out of reach of children.
Overdose
Overdose is unlikely with vaginal administration. Symptoms may include drowsiness, dizziness, or short-lived mood changes. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Used to support early pregnancy and prevent preterm birth. Not recommended during lactation as progesterone can pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, specific to the product.
Availability
Pharmacies, hospitals
Approval Status
Approved by health authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Progesterone has been extensively studied in clinical trials for luteal phase support in ART, prevention of recurrent miscarriage, and prevention of preterm birth, demonstrating established efficacy and safety.
Lab Monitoring
- Regular pregnancy tests if used for fertility
- Progesterone levels (if deemed necessary by physician)
- Liver function tests (in patients with pre-existing hepatic impairment)
Doctor Notes
- Crucial for early pregnancy support; ensure proper patient counseling on correct administration technique and potential side effects.
- Monitor for signs of allergic reaction, abnormal bleeding, or thromboembolic events.
- Individualize treatment duration based on clinical need and specific indication.
Patient Guidelines
- Follow your doctor's instructions carefully regarding dosage and duration.
- Insert the pessary deeply into the vagina, preferably lying down.
- Report any unusual bleeding, severe pain, or allergic reactions to your doctor.
- Do not use if you are allergic to progesterone or any other ingredients.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose to make up for a missed one.
Driving Precautions
May cause dizziness or drowsiness in some individuals. Avoid driving or operating machinery if you experience these effects.
Lifestyle Advice
- Maintain a healthy diet and lifestyle throughout your treatment.
- Avoid sexual intercourse immediately after insertion to prevent expulsion or reduce efficacy.
- Discuss any concerns about weight gain or mood changes with your doctor.
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