Miganil
Generic Name
Pizotifen 5 mg tablet
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| miganil 5 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Miganil (Pizotifen) is an antihistamine and serotonin antagonist used for the prophylaxis of migraine and other vascular headaches. It may also have appetite stimulant properties.
Uses & Indications
Dosage
Adults
Normally, 0.5-1.5 mg daily, gradually increased to 1.5-3 mg daily in divided doses or as a single dose at night. A single 5 mg tablet (if prescribed) would be considered a high daily dose and should be taken with extreme caution, likely once daily at night, under strict medical supervision. Maximum recommended daily dose is typically 4.5 mg.
Elderly
Start with lower doses (e.g., 0.5 mg daily) and titrate carefully due to increased sensitivity to side effects.
Renal_impairment
Use with caution. Dosage reduction might be necessary due to altered excretion.
How to Take
Oral administration. Can be taken with or without food. To minimize sedation, especially with higher doses like 5mg, it is often recommended to take the dose at night. Start with a low dose and gradually increase.
Mechanism of Action
Pizotifen acts as a serotonin (5-HT1 and 5-HT2) antagonist and has antihistaminic (H1) and weak anticholinergic properties. It is believed to work in migraine prophylaxis by reducing serotonin-induced vasoconstriction and by stabilizing mast cells. It also increases appetite.
Pharmacokinetics
Onset
Prophylactic effect develops over several weeks of consistent use.
Excretion
Mainly excreted in urine (about 50%) as metabolites, and a smaller amount in feces.
Half life
Approximately 20-30 hours.
Absorption
Well absorbed orally. Peak plasma levels usually reached within 3-4 hours.
Metabolism
Extensively metabolized in the liver, primarily by glucuronidation.
Side Effects
Contraindications
- •Hypersensitivity to pizotifen or any components of the formulation
- •Acute angle-closure glaucoma
- •Urinary retention
Drug Interactions
MAOIs
Potential for enhanced effects, although specific interaction data for pizotifen is limited.
Anticholinergics
May enhance anticholinergic effects such as dry mouth and urinary retention.
CNS Depressants (e.g., alcohol, sedatives, hypnotics)
Concurrent use may enhance the sedative effects.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include drowsiness, confusion, disorientation, tachycardia, hypotension, coma, and convulsions. Management involves gastric lavage, activated charcoal, and symptomatic and supportive treatment. Maintain airway, breathing, and circulation.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and the potential benefits outweigh the risks. Not recommended during breastfeeding as pizotifen is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Available in pharmacies
Approval Status
Approved for migraine prophylaxis in many countries
Patent Status
Off-patent
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Global Brand Names
International brand names for this medicine
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