Minomal-R
Generic Name
minomal-r-175-mg-tablet
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| minomal r 175 mg tablet | ৳ 1.23 | ৳ 12.30 |
Description
Overview of the medicine
Minomal-R 175 mg tablet is an extended-release formulation of Minocycline, a tetracycline antibiotic. It is primarily used for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris and for the treatment of rosacea.
Uses & Indications
Dosage
Adults
175 mg orally once daily. Typically for 6 to 12 weeks for acne or as directed by a physician.
Elderly
No specific dosage adjustment is generally required, but caution is advised in patients with renal or hepatic impairment.
Renal_impairment
Use with caution in severe renal impairment; dose reduction may be necessary.
How to Take
Take the tablet whole with a full glass of water. Do not crush, break, or chew. It can be taken with or without food, but consistency is recommended.
Mechanism of Action
Minocycline exerts its antibacterial action by inhibiting bacterial protein synthesis. It binds reversibly to the 30S ribosomal subunit of susceptible bacteria, thereby blocking the binding of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. This prevents the addition of new amino acids to the growing peptide chain and inhibits protein synthesis. Its anti-inflammatory effects contribute to its efficacy in acne and rosacea.
Pharmacokinetics
Onset
Antibacterial effects within hours; clinical improvement in acne may take weeks.
Excretion
Excreted primarily through glomerular filtration in the urine and also via feces.
Half life
Approximately 11-26 hours (extended-release formulations).
Absorption
Well absorbed from the gastrointestinal tract, though absorption may be affected by food and dairy products.
Metabolism
Partially metabolized in the liver, forming several inactive metabolites.
Side Effects
Contraindications
- Known hypersensitivity to minocycline or other tetracyclines.
- Severe hepatic impairment.
- Pregnancy and lactation (especially during the second and third trimesters of pregnancy due to potential for permanent tooth discoloration and bone growth inhibition in the fetus).
- Children under 12 years of age.
Drug Interactions
Warfarin
Tetracyclines may potentiate the anticoagulant effect of warfarin. Monitor INR closely.
Penicillins
Tetracyclines may interfere with the bactericidal action of penicillins. Avoid co-administration.
Isotretinoin
Concurrent use may increase the risk of pseudotumor cerebri. Avoid co-administration.
Oral contraceptives
May decrease the effectiveness of oral contraceptives, leading to breakthrough bleeding or unintended pregnancy.
Antacids containing aluminum, calcium, or magnesium
May decrease the absorption of minocycline. Separate administration by at least 2 hours.
Iron preparations and multivitamins containing iron
May decrease the absorption of minocycline. Separate administration by at least 2 hours.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, discontinue the drug and institute symptomatic and supportive therapy. Gastric lavage may be considered within the first few hours. Minocycline is not significantly removed by hemodialysis.
Pregnancy & Lactation
Minocycline is contraindicated in pregnancy (Pregnancy Category D) due to potential for permanent tooth discoloration and inhibition of bone growth in the fetus. It is also excreted in breast milk and should not be used during lactation.
Side Effects
Contraindications
- Known hypersensitivity to minocycline or other tetracyclines.
- Severe hepatic impairment.
- Pregnancy and lactation (especially during the second and third trimesters of pregnancy due to potential for permanent tooth discoloration and bone growth inhibition in the fetus).
- Children under 12 years of age.
Drug Interactions
Warfarin
Tetracyclines may potentiate the anticoagulant effect of warfarin. Monitor INR closely.
Penicillins
Tetracyclines may interfere with the bactericidal action of penicillins. Avoid co-administration.
Isotretinoin
Concurrent use may increase the risk of pseudotumor cerebri. Avoid co-administration.
Oral contraceptives
May decrease the effectiveness of oral contraceptives, leading to breakthrough bleeding or unintended pregnancy.
Antacids containing aluminum, calcium, or magnesium
May decrease the absorption of minocycline. Separate administration by at least 2 hours.
Iron preparations and multivitamins containing iron
May decrease the absorption of minocycline. Separate administration by at least 2 hours.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, discontinue the drug and institute symptomatic and supportive therapy. Gastric lavage may be considered within the first few hours. Minocycline is not significantly removed by hemodialysis.
Pregnancy & Lactation
Minocycline is contraindicated in pregnancy (Pregnancy Category D) due to potential for permanent tooth discoloration and inhibition of bone growth in the fetus. It is also excreted in breast milk and should not be used during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved (Hypothetical)
Patent Status
Expired for generic, possible for specific formulation
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of minocycline extended-release formulations in the treatment of moderate to severe acne vulgaris and rosacea, showing significant reduction in inflammatory lesion counts compared to placebo.
Lab Monitoring
- Monitor liver function tests (LFTs) periodically, especially in patients with pre-existing hepatic impairment or during prolonged therapy.
- Monitor renal function tests (RFTs) in patients with known renal impairment.
Doctor Notes
- Advise patients to report any signs of hypersensitivity reactions or severe gastrointestinal upset.
- Monitor for signs of increased intracranial pressure (headache, vision changes) especially in younger patients.
- Emphasize the importance of sun protection due to photosensitivity.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Avoid prolonged exposure to sunlight or tanning beds; use sunscreen and wear protective clothing.
- Report any unusual or severe side effects, especially persistent headache, vision changes, or severe dizziness, to your doctor immediately.
- Do not use in children under 12 years of age.
- Drink plenty of fluids while on this medication.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.
Driving Precautions
Minomal-R may cause dizziness, lightheadedness, or vertigo. Patients should be cautioned about driving or operating hazardous machinery until they know how the drug affects them.
Lifestyle Advice
- Maintain good skin hygiene for acne management.
- Stay hydrated to minimize gastrointestinal discomfort.
- Avoid alcohol consumption during treatment if it exacerbates side effects.
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