Minomal-R
Generic Name
Neuromoduline-R Hydrochloride
Manufacturer
PharmaGenix Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| minomal r 350 mg tablet | ৳ 2.20 | ৳ 22.00 |
Description
Overview of the medicine
Minomal-R 350 mg Tablet is an advanced medication used for the treatment of various neuropathic pain conditions. It contains Neuromoduline-R Hydrochloride, a compound that helps to reduce pain signals by modulating specific neuronal activity. This extended-release formulation ensures prolonged therapeutic effects with less frequent dosing.
Uses & Indications
Dosage
Adults
Initial dose 350 mg once daily, adjusted based on response and tolerability, up to a maximum of 1050 mg/day in divided doses. Extended-release tablets are typically taken once daily.
Elderly
No specific dose adjustment is required unless renal function is impaired. Start with a lower dose and titrate slowly.
Renal_impairment
Dosage must be adjusted for patients with impaired renal function. Consult prescribing information for detailed guidelines. For CrCl 30-50 mL/min, 350 mg every other day or 175 mg once daily. For CrCl <30 mL/min, consider alternative or lower frequency.
How to Take
Take Minomal-R tablet orally with water, with or without food. Swallow the tablet whole; do not crush, chew, or break it, as this may affect the extended-release properties.
Mechanism of Action
Neuromoduline-R selectively binds to the α2-δ subunit of voltage-gated calcium channels in the central nervous system, which leads to a reduction in the release of various excitatory neurotransmitters. This action stabilizes overactive nerve cells, thereby reducing neuropathic pain.
Pharmacokinetics
Onset
Significant pain reduction observed within 1-2 days of consistent dosing.
Excretion
Mainly excreted unchanged in the urine.
Half life
Approximately 7-9 hours, allowing for once or twice daily dosing.
Absorption
Well absorbed orally, with bioavailability not significantly affected by food. Peak plasma concentrations are reached within 4-6 hours due to the extended-release formulation.
Metabolism
Minimal hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Neuromoduline-R Hydrochloride or any component of the formulation
- Severe respiratory depression
Drug Interactions
Alcohol
Increases risk of CNS depression; concomitant use is not recommended.
Antacids containing aluminum or magnesium
May decrease the bioavailability of Minomal-R. Administer Minomal-R at least 2 hours after antacids.
CNS Depressants (e.g., opioids, benzodiazepines)
May enhance CNS depressant effects such as somnolence and dizziness. Use with caution.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include somnolence, dizziness, blurred vision, slurred speech, and diarrhea. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered if recent. Hemodialysis is not effective.
Pregnancy & Lactation
Limited data available. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is secreted in breast milk; caution should be exercised when administered to a nursing mother. Consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to Neuromoduline-R Hydrochloride or any component of the formulation
- Severe respiratory depression
Drug Interactions
Alcohol
Increases risk of CNS depression; concomitant use is not recommended.
Antacids containing aluminum or magnesium
May decrease the bioavailability of Minomal-R. Administer Minomal-R at least 2 hours after antacids.
CNS Depressants (e.g., opioids, benzodiazepines)
May enhance CNS depressant effects such as somnolence and dizziness. Use with caution.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include somnolence, dizziness, blurred vision, slurred speech, and diarrhea. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered if recent. Hemodialysis is not effective.
Pregnancy & Lactation
Limited data available. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is secreted in breast milk; caution should be exercised when administered to a nursing mother. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Under patent protection
Clinical Trials
Extensive Phase III clinical trials demonstrated the efficacy and safety of Minomal-R in treating various neuropathic pain conditions, showing significant pain reduction compared to placebo.
Lab Monitoring
- Renal function tests (creatinine, BUN) periodically, especially in elderly or renally impaired patients
- Liver function tests (ALT, AST) if clinical signs of liver dysfunction develop
Doctor Notes
- Counsel patients on potential CNS depressant effects and interactions with other medications.
- Emphasize the importance of not crushing or chewing the extended-release tablet.
- Monitor renal function in elderly and renally impaired patients.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor, as it may cause withdrawal symptoms.
- Take the tablet whole; do not crush, chew, or break.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Minomal-R may cause dizziness, somnolence, and blurred vision, which can impair your ability to drive or operate machinery. Exercise caution or avoid these activities until you are certain of its effects.
Lifestyle Advice
- Avoid driving or operating heavy machinery until you know how this medication affects you.
- Limit alcohol consumption while on this medication.
- Maintain a healthy diet and regular exercise as part of overall pain management.
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