Miroflex
Generic Name
Baclofen
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| miroflex 25 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Miroflex 25 mg Tablet contains Baclofen, a centrally acting skeletal muscle relaxant used to treat muscle spasticity resulting from multiple sclerosis, spinal cord injuries, or other spinal cord diseases.
Uses & Indications
Dosage
Adults
Initially 5 mg three times daily, gradually increasing by 5 mg increments every 3 days to a maximum of 20 mg three times daily. Some patients may require up to 100 mg daily.
Elderly
Lower initial doses are recommended, with careful titration due to increased sensitivity and potential for adverse effects.
Renal_impairment
Dose reduction is necessary. For mild to moderate impairment, consider halving the dose. For severe impairment or dialysis patients, use with extreme caution and very low doses.
How to Take
Administer orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Baclofen is a gamma-aminobutyric acid (GABA) derivative that acts as a GABA-B receptor agonist. It works by inhibiting both monosynaptic and polysynaptic reflexes at the spinal level, thereby reducing muscle hypertonicity and spasticity.
Pharmacokinetics
Onset
Typically within 1-2 hours
Excretion
Mainly excreted unchanged by the kidneys (70-80%) via urine. A small amount is excreted in feces.
Half life
Approximately 3-4 hours
Absorption
Rapidly and extensively absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 2-3 hours.
Metabolism
Minimally metabolized in the liver; approximately 15% is metabolized to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to baclofen or any component of the formulation
- Epilepsy (use with caution)
Drug Interactions
Antihypertensives
Potentiation of hypotensive effects.
Tricyclic Antidepressants
Potentiation of muscle relaxant effect leading to increased weakness.
CNS Depressants (e.g., alcohol, benzodiazepines)
Increased CNS depression, drowsiness, and respiratory depression.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, lightheadedness, nausea, vomiting, respiratory depression, seizures, and coma. Treatment is supportive; maintain airway, breathing, and circulation. Activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to baclofen or any component of the formulation
- Epilepsy (use with caution)
Drug Interactions
Antihypertensives
Potentiation of hypotensive effects.
Tricyclic Antidepressants
Potentiation of muscle relaxant effect leading to increased weakness.
CNS Depressants (e.g., alcohol, benzodiazepines)
Increased CNS depression, drowsiness, and respiratory depression.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, lightheadedness, nausea, vomiting, respiratory depression, seizures, and coma. Treatment is supportive; maintain airway, breathing, and circulation. Activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by relevant authorities (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Baclofen has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in treating spasticity of various origins. Ongoing research explores its potential in other neurological conditions.
Lab Monitoring
- Renal function tests (e.g., creatinine, BUN) periodically, especially in patients with impaired renal function.
- Liver function tests (LFTs) if abnormalities are suspected.
Doctor Notes
- Start low, go slow (titrate dose gradually to avoid adverse effects).
- Counsel patients on withdrawal symptoms and importance of not stopping abruptly.
- Monitor renal function, especially in elderly or renally impaired patients.
Patient Guidelines
- Do not suddenly stop taking this medicine without consulting your doctor.
- Avoid driving or operating heavy machinery until you know how this medicine affects you.
- Avoid alcohol while taking Miroflex.
- Report any unusual side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Miroflex can cause drowsiness, dizziness, and impaired coordination. Do not drive or operate heavy machinery until you are certain that the medicine does not adversely affect your ability to perform such tasks.
Lifestyle Advice
- Engage in physical therapy as recommended by your doctor to manage spasticity.
- Maintain a balanced diet and stay hydrated.
- Ensure adequate rest and sleep.
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