Miroflex
Generic Name
Baclofen 5 mg Tablet
Manufacturer
Hypothetical Manufacturer
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| miroflex 5 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Miroflex 5 mg Tablet contains Baclofen, which is a muscle relaxant used to treat muscle spasms, stiffness, and pain caused by certain conditions like multiple sclerosis, spinal cord injury, or other neurological disorders. It works by decreasing nerve impulses that cause muscle spasms.
Uses & Indications
Dosage
Adults
Initial dosage is 5 mg three times daily, preferably with meals. The dose should be gradually increased at 3-day intervals by 5 mg three times daily, up to a maximum of 20 mg three times daily (60 mg/day). Some patients may require up to 80-100 mg/day.
Elderly
Start with a lower dose (e.g., 5 mg twice daily) and increase gradually under close medical supervision due to increased sensitivity to side effects.
Renal_impairment
Dosage should be reduced in patients with impaired renal function. Consult physician for specific recommendations based on creatinine clearance.
How to Take
Take Miroflex 5 mg Tablet orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.
Mechanism of Action
Baclofen is a gamma-aminobutyric acid (GABA) derivative that acts as an agonist at GABA-B receptors. By activating these receptors, it hyperpolarizes afferent terminals and inhibits both monosynaptic and polysynaptic reflexes at the spinal cord level. This leads to a reduction in muscle spasticity and associated pain.
Pharmacokinetics
Onset
Muscle relaxant effects may begin within hours of the first dose, with peak effects observed after several days of treatment.
Excretion
Primarily excreted unchanged by the kidneys (70-80% within 72 hours). A small amount is excreted in the feces.
Half life
3-4 hours
Absorption
Rapidly and extensively absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 2-3 hours.
Metabolism
Approximately 5% of the dose is metabolized in the liver by deamination. The major metabolite is beta-(p-chlorophenyl)-gamma-hydroxybutyric acid.
Side Effects
Contraindications
- Hypersensitivity to Baclofen or any component of the tablet
- Acute porphyria
Drug Interactions
Antihypertensives
May enhance the hypotensive effects of antihypertensive drugs.
Levodopa/Carbidopa
Increased risk of hallucinations, confusion, and agitation in Parkinson's patients.
Antidepressants (e.g., tricyclic antidepressants, MAO inhibitors)
May potentiate the sedative effects of Baclofen and increase the risk of CNS depression.
Central Nervous System (CNS) Depressants (e.g., alcohol, benzodiazepines, opioids)
Increased CNS depressant effects, including sedation and respiratory depression.
Storage
Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe drowsiness, dizziness, confusion, respiratory depression, seizures, and coma. Management involves supportive care, maintaining airway, breathing, and circulation. Gastric lavage may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C. Baclofen should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to Baclofen or any component of the tablet
- Acute porphyria
Drug Interactions
Antihypertensives
May enhance the hypotensive effects of antihypertensive drugs.
Levodopa/Carbidopa
Increased risk of hallucinations, confusion, and agitation in Parkinson's patients.
Antidepressants (e.g., tricyclic antidepressants, MAO inhibitors)
May potentiate the sedative effects of Baclofen and increase the risk of CNS depression.
Central Nervous System (CNS) Depressants (e.g., alcohol, benzodiazepines, opioids)
Increased CNS depressant effects, including sedation and respiratory depression.
Storage
Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe drowsiness, dizziness, confusion, respiratory depression, seizures, and coma. Management involves supportive care, maintaining airway, breathing, and circulation. Gastric lavage may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C. Baclofen should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture, depending on storage conditions.
Availability
Available in pharmacies and hospitals
Approval Status
Approved (Generic)
Patent Status
Generic, Patent Expired
Clinical Trials
Baclofen has been extensively studied in numerous clinical trials demonstrating its efficacy in reducing spasticity due to various neurological conditions. Ongoing research focuses on optimizing delivery methods and managing side effects.
Lab Monitoring
- Regular monitoring of renal function (creatinine clearance) is recommended, especially in elderly patients or those with kidney impairment.
- Liver function tests may be considered in patients on long-term therapy.
Doctor Notes
- Initiate Baclofen therapy at a low dose and titrate slowly to avoid adverse effects.
- Emphasize the importance of gradual dose reduction to patients to prevent withdrawal symptoms.
- Monitor for CNS depression, especially when co-administered with other sedatives.
Patient Guidelines
- Do not suddenly stop taking Miroflex, as this can lead to serious withdrawal symptoms. The dose should be reduced gradually over 1-2 weeks.
- Avoid driving or operating heavy machinery until you know how this medication affects you, as it can cause drowsiness and dizziness.
- Report any unusual side effects or worsening of your condition to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Miroflex can cause drowsiness, dizziness, and confusion. Patients should be advised not to drive or operate machinery if they experience these effects.
Lifestyle Advice
- Avoid alcohol consumption while taking this medicine as it can increase side effects like drowsiness.
- Engage in physical therapy as recommended by your doctor to manage spasticity effectively.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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