Molukat
Generic Name
Montelukast
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| molukat 10 mg tablet | ৳ 12.04 | N/A |
Description
Overview of the medicine
Molukat 10 mg Tablet contains Montelukast, a leukotriene receptor antagonist used for the prevention and long-term treatment of asthma in adults and pediatric patients 6 years and older, and for the relief of symptoms of seasonal and perennial allergic rhinitis.
Uses & Indications
Dosage
Adults
10 mg orally once daily in the evening.
Elderly
No dosage adjustment necessary.
Renal_impairment
No dosage adjustment necessary.
How to Take
Take orally once daily in the evening, with or without food.
Mechanism of Action
Montelukast selectively antagonizes the CysLT1 receptor. Cysteinyl leukotrienes (LTC4, LTD4, LTE4) are potent eicosanoids released from various cells, including mast cells and eosinophils, that bind to CysLT1 receptors and contribute to asthma and allergic rhinitis pathophysiology, including bronchoconstriction, mucus secretion, vascular permeability, and eosinophil recruitment. Montelukast inhibits these effects.
Pharmacokinetics
Onset
Improvement in asthma control within 1 day.
Excretion
Excreted almost exclusively via bile into the feces.
Half life
Plasma half-life is 2.7 to 5.5 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentration is reached in 2-4 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4, 2C8, and 2C9.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation
Drug Interactions
Rifampicin
May decrease montelukast plasma concentrations.
Phenobarbital
May decrease montelukast plasma concentrations.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek emergency medical attention. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Montelukast is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation
Drug Interactions
Rifampicin
May decrease montelukast plasma concentrations.
Phenobarbital
May decrease montelukast plasma concentrations.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek emergency medical attention. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Montelukast is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA and FDA
Patent Status
Off-patent
Clinical Trials
Molukat 10 mg Tablet is a generic formulation of Montelukast and has demonstrated bioequivalence to the innovator drug. Clinical trials for Montelukast have shown efficacy in improving asthma control and allergic rhinitis symptoms.
Lab Monitoring
- No specific routine lab monitoring required.
- Monitor for signs of eosinophilia or Churg-Strauss syndrome in some cases.
Doctor Notes
- Advise patients that Molukat is for prophylaxis and chronic treatment, not for acute asthma attacks.
- Monitor patients for neuropsychiatric changes.
- Counsel on proper administration and adherence.
Patient Guidelines
- Take this medicine regularly, even if you feel well.
- Do not stop taking this medicine suddenly without consulting your doctor.
- Inform your doctor if you experience any unusual mood or behavior changes.
- This medicine is not for treating acute asthma attacks.
Missed Dose Advice
If a dose is missed, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or drowsiness in some individuals. Exercise caution when driving or operating machinery.
Lifestyle Advice
- Identify and avoid asthma and allergy triggers (e.g., dust mites, pollen, pet dander).
- Maintain a healthy lifestyle with regular exercise and a balanced diet.
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Global Brand Names
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