Oral administration. Take one tablet daily in the evening, with or without food.

Montelukast selectively blocks the action of leukotrienes (LTD4, LTE4, and LTC4) on the CysLT1 receptor in the airways and on proinflammatory cells. Leukotrienes are potent inflammatory mediators released from various cells, including mast cells and eosinophils, and are responsible for bronchoconstriction, mucus secretion, vascular permeability, and eosinophil recruitment, all of which contribute to asthma and allergic rhinitis symptoms.

• •Hypersensitivity to the active substance or to any of the excipients

Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.

No specific antidote. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered in some cases.

Pregnancy Category B. Use during pregnancy only if clearly needed. Montelukast is excreted in breast milk; caution should be exercised when administered to a nursing mother.