Moxifix
Generic Name
Moxifloxacin
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| moxifix 400 mg injection | ৳ 350.00 | N/A |
Description
Overview of the medicine
Moxifloxacin is a fourth-generation synthetic broad-spectrum fluoroquinolone antibacterial agent. It is used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
400 mg once daily by intravenous infusion over 60 minutes for 5-21 days, depending on the infection type.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is required for patients with mild, moderate, or severe renal impairment, or for patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD).
How to Take
Administer by intravenous infusion over a period of 60 minutes. Do not administer as a rapid or bolus injection. It can be diluted with compatible solutions like 0.9% sodium chloride.
Mechanism of Action
Moxifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This leads to bacterial cell death.
Pharmacokinetics
Onset
Rapid, typically within minutes of intravenous infusion.
Excretion
Excreted both renally (approximately 20% unchanged) and hepatically/biliary (approximately 25% unchanged). Total body clearance is about 12 L/h.
Half life
Approximately 12-15 hours, allowing for once-daily dosing.
Absorption
Rapid and complete absorption after oral administration, however, for IV injection, bioavailability is 100%. Peak plasma concentrations are reached shortly after infusion.
Metabolism
Primarily metabolized in the liver via glucuronide and sulfate conjugation. These metabolites are inactive.
Side Effects
Contraindications
- Hypersensitivity to moxifloxacin or other quinolones.
- Patients with a history of QTc prolongation, uncorrected hypokalemia, or taking Class IA or Class III antiarrhythmics.
- History of tendon disorders related to fluoroquinolone administration.
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring INR monitoring.
Corticosteroids
Increased risk of tendinitis and tendon rupture when co-administered with fluoroquinolones.
Class IA and Class III Antiarrhythmics
Increased risk of QTc prolongation, concurrent use is contraindicated.
Antacids, Sucralfate, Iron/Zinc Supplements
Reduced absorption if given orally (not applicable for injection, but relevant for oral forms if therapy switched).
Storage
Store below 30°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
In case of overdose, supportive measures should be taken, including monitoring of ECG for QTc prolongation. There is no specific antidote. Hemodialysis or peritoneal dialysis may remove a small amount of drug.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Moxifloxacin is excreted into human milk; therefore, breastfeeding is not recommended.
Side Effects
Contraindications
- Hypersensitivity to moxifloxacin or other quinolones.
- Patients with a history of QTc prolongation, uncorrected hypokalemia, or taking Class IA or Class III antiarrhythmics.
- History of tendon disorders related to fluoroquinolone administration.
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring INR monitoring.
Corticosteroids
Increased risk of tendinitis and tendon rupture when co-administered with fluoroquinolones.
Class IA and Class III Antiarrhythmics
Increased risk of QTc prolongation, concurrent use is contraindicated.
Antacids, Sucralfate, Iron/Zinc Supplements
Reduced absorption if given orally (not applicable for injection, but relevant for oral forms if therapy switched).
Storage
Store below 30°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
In case of overdose, supportive measures should be taken, including monitoring of ECG for QTc prolongation. There is no specific antidote. Hemodialysis or peritoneal dialysis may remove a small amount of drug.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Moxifloxacin is excreted into human milk; therefore, breastfeeding is not recommended.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months, as indicated on the packaging.
Availability
Hospitals and Pharmacies
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of moxifloxacin in various bacterial infections. Ongoing post-marketing surveillance continues to monitor for rare adverse events.
Lab Monitoring
- ECG monitoring (especially in patients at risk for QTc prolongation)
- Liver function tests (LFTs)
- Renal function tests (RFTs)
- Electrolyte levels (potassium, magnesium)
Doctor Notes
- Carefully assess risk factors for QTc prolongation before prescribing.
- Counsel patients on the risk of tendon rupture and peripheral neuropathy, advising them to discontinue the drug and seek medical attention if symptoms occur.
- Monitor liver function in patients with pre-existing hepatic impairment.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve.
- Report any new or worsening side effects, especially joint pain, muscle weakness, or changes in sensation.
- Avoid excessive sun exposure due to potential photosensitivity.
- Do not drive or operate machinery if experiencing dizziness or visual disturbances.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Moxifloxacin may cause dizziness, lightheadedness, or visual disturbances. Patients should be advised not to drive or operate machinery if they experience these symptoms.
Lifestyle Advice
- Stay well-hydrated during treatment.
- Avoid alcohol consumption as it may exacerbate some side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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