Moxifix
Generic Name
Moxifloxacin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| moxifix 400 mg tablet | ৳ 70.00 | ৳ 280.00 |
Description
Overview of the medicine
Moxifloxacin is a fluoroquinolone antibiotic used to treat a variety of bacterial infections, including those of the respiratory tract, skin, and abdomen.
Uses & Indications
Dosage
Adults
400 mg once daily for 5-21 days, depending on the infection type and severity. Should be swallowed whole with water.
Elderly
No dose adjustment is typically required based on age alone.
Renal_impairment
No dose adjustment is necessary for patients with mild to moderate renal impairment (CrCl >30 mL/min) or for patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD).
How to Take
Take orally, with or without food. Swallow the tablet whole with a glass of water; do not crush, chew, or break.
Mechanism of Action
Moxifloxacin inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Variable, typically within 1-2 hours for significant plasma concentrations to be reached.
Excretion
Approximately 20% of the dose is excreted unchanged in urine and 25% in feces. Both renal and hepatic routes contribute to elimination.
Half life
Approximately 12-15 hours, allowing for once-daily dosing.
Absorption
Rapid and well absorbed from the gastrointestinal tract, with an absolute bioavailability of approximately 90%. Peak plasma concentrations are achieved within 0.5-4 hours.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation, forming inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to moxifloxacin or other quinolones
- History of tendinopathy or tendon rupture associated with quinolone use
- Congenital or documented acquired QT prolongation
- Electrolyte disturbances, particularly uncorrected hypokalemia
- Severe hepatic impairment
Drug Interactions
Warfarin
Potential for increased anticoagulant effect, monitor INR.
Corticosteroids
Increased risk of tendinopathy and tendon rupture.
Antacids, sucralfate, didanosine, mineral supplements
May decrease moxifloxacin absorption. Administer moxifloxacin several hours before or after these agents.
Class IA and Class III antiarrhythmics (e.g., quinidine, procainamide, amiodarone, sotalol)
Increased risk of QT prolongation. Co-administration should be avoided.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children.
Overdose
In case of an overdose, symptomatic and supportive treatment should be initiated. ECG monitoring is recommended due to the risk of QT prolongation. Hemodialysis or peritoneal dialysis may not be effective in removing moxifloxacin.
Pregnancy & Lactation
Not recommended during pregnancy unless the potential benefit outweighs the potential risk to the fetus. Moxifloxacin is excreted into breast milk; therefore, its use is not recommended during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to moxifloxacin or other quinolones
- History of tendinopathy or tendon rupture associated with quinolone use
- Congenital or documented acquired QT prolongation
- Electrolyte disturbances, particularly uncorrected hypokalemia
- Severe hepatic impairment
Drug Interactions
Warfarin
Potential for increased anticoagulant effect, monitor INR.
Corticosteroids
Increased risk of tendinopathy and tendon rupture.
Antacids, sucralfate, didanosine, mineral supplements
May decrease moxifloxacin absorption. Administer moxifloxacin several hours before or after these agents.
Class IA and Class III antiarrhythmics (e.g., quinidine, procainamide, amiodarone, sotalol)
Increased risk of QT prolongation. Co-administration should be avoided.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children.
Overdose
In case of an overdose, symptomatic and supportive treatment should be initiated. ECG monitoring is recommended due to the risk of QT prolongation. Hemodialysis or peritoneal dialysis may not be effective in removing moxifloxacin.
Pregnancy & Lactation
Not recommended during pregnancy unless the potential benefit outweighs the potential risk to the fetus. Moxifloxacin is excreted into breast milk; therefore, its use is not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Moxifloxacin has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in various bacterial infections, including respiratory tract, skin, and complicated intra-abdominal infections, often compared with other standard antibiotics.
Lab Monitoring
- Liver function tests (LFTs) if prolonged use or pre-existing liver conditions.
- Renal function tests (RFTs) if underlying kidney disease.
- ECG monitoring for QT interval in patients with risk factors for QT prolongation.
Doctor Notes
- Emphasize the black box warnings to patients regarding tendinopathy, peripheral neuropathy, and CNS effects. Instruct patients to discontinue the drug and contact a healthcare professional immediately if these adverse effects occur.
- Monitor for QT prolongation in patients with risk factors. Avoid co-administration with Class IA and Class III antiarrhythmics.
- Consider the risk-benefit profile carefully, especially in patients with less severe infections where other treatment options are available.
Patient Guidelines
- Complete the entire course of treatment as prescribed, even if symptoms improve.
- Avoid excessive exposure to direct sunlight or artificial UV light while taking this medication and for several days afterwards, as photosensitivity may occur.
- Report any new or worsening tendon pain, numbness, tingling, or weakness to your doctor immediately.
- Avoid taking antacids or mineral supplements within several hours of taking Moxifix.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Moxifloxacin may cause dizziness or lightheadedness, and in rare cases, visual disturbances. Patients should assess their reaction to the drug before driving or operating machinery.
Lifestyle Advice
- Maintain good hydration throughout the treatment period.
- Avoid excessive caffeine and alcohol consumption.
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