Multiparin
Generic Name
Enoxaparin Sodium
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| multiparin 25000 iu injection | ৳ 554.00 | N/A |
Description
Overview of the medicine
Multiparin is an anticoagulant (blood thinner) used to prevent and treat blood clots (deep vein thrombosis and pulmonary embolism) and in certain cardiac conditions.
Uses & Indications
Dosage
Adults
Dosage varies based on indication (prophylaxis or treatment) and patient weight, typically 20-80 mg subcutaneously once or twice daily.
Elderly
No dose adjustment generally required unless severe renal impairment. Monitor closely.
Renal_impairment
Dose adjustment required for severe renal impairment (CrCl < 30 mL/min). Usually 20 mg once daily for prophylaxis, 1 mg/kg once daily for treatment.
How to Take
Administer by subcutaneous injection, usually into the anterolateral or posterolateral abdominal wall. Do not inject intramuscularly.
Mechanism of Action
Potentiates the inhibitory effect of antithrombin III on Factor Xa and thrombin (Factor IIa), with a preferential effect on Factor Xa.
Pharmacokinetics
Onset
Anti-Xa activity peaks within 3-5 hours after subcutaneous administration.
Excretion
Primarily renal excretion of active and inactive fragments.
Half life
Approximately 4.5 to 7 hours (anti-Xa activity) after subcutaneous administration.
Absorption
Rapid and complete after subcutaneous injection, with peak anti-Xa activity within 3-5 hours.
Metabolism
Hepatic desulfation and depolymerization into lower molecular weight species.
Side Effects
Contraindications
- Hypersensitivity to enoxaparin, heparin, or pork products.
- Active major bleeding or conditions with high risk of uncontrolled bleeding.
- History of heparin-induced thrombocytopenia (HIT) within the last 100 days or presence of circulating antibodies.
- Spinal/epidural anesthesia or lumbar puncture in patients on therapeutic anticoagulation due to risk of spinal hematoma.
Drug Interactions
Other LMWHs or heparins
Increased risk of bleeding.
Antiplatelet agents (e.g., aspirin, clopidogrel), NSAIDs, oral anticoagulants (e.g., warfarin), thrombolytics
Increased risk of bleeding.
Storage
Store below 30°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
Accidental overdose may lead to hemorrhagic complications. Antidote is protamine sulfate (1 mg protamine neutralizes 1 mg enoxaparin).
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed during pregnancy. Small amounts may be excreted in breast milk, but generally considered compatible with breastfeeding with caution.
Side Effects
Contraindications
- Hypersensitivity to enoxaparin, heparin, or pork products.
- Active major bleeding or conditions with high risk of uncontrolled bleeding.
- History of heparin-induced thrombocytopenia (HIT) within the last 100 days or presence of circulating antibodies.
- Spinal/epidural anesthesia or lumbar puncture in patients on therapeutic anticoagulation due to risk of spinal hematoma.
Drug Interactions
Other LMWHs or heparins
Increased risk of bleeding.
Antiplatelet agents (e.g., aspirin, clopidogrel), NSAIDs, oral anticoagulants (e.g., warfarin), thrombolytics
Increased risk of bleeding.
Storage
Store below 30°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
Accidental overdose may lead to hemorrhagic complications. Antidote is protamine sulfate (1 mg protamine neutralizes 1 mg enoxaparin).
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed during pregnancy. Small amounts may be excreted in breast milk, but generally considered compatible with breastfeeding with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to packaging for exact expiry date.
Availability
Hospitals, pharmacies
Approval Status
Approved by DGDA and international regulatory bodies
Patent Status
Generics available
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials demonstrating efficacy and safety in various thrombotic conditions.
Lab Monitoring
- Platelet count (monitor for HIT)
- Anti-Xa levels (in specific populations like renal impairment or extremes of weight)
- Renal function (CrCl)
- Hemoglobin/hematocrit
Doctor Notes
- Consider renal function for dose adjustment, especially in elderly.
- Careful monitoring for signs of bleeding or HIT.
- Avoid concomitant use with other anticoagulants/antiplatelets unless specifically indicated and closely monitored.
Patient Guidelines
- Administer exactly as prescribed by your doctor. Do not change dose or stop without consulting.
- Learn proper self-injection technique if applicable.
- Report any unusual bleeding, bruising, or signs of allergic reaction immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and continue your regular schedule. Do not double the dose.
Driving Precautions
Generally no direct effect on ability to drive or operate machinery. However, if experiencing dizziness or other side effects, avoid driving.
Lifestyle Advice
- Avoid activities that may increase risk of injury or bleeding.
- Inform all healthcare providers, including dentists, that you are taking this medication.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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