Mupiron
Generic Name
Mupirocin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mupiron 2 w ointment | ৳ 140.00 | N/A |
Description
Overview of the medicine
Mupirocin is a topical antibiotic used to treat bacterial skin infections such as impetigo, folliculitis, and furunculosis. It works by stopping the growth of certain bacteria.
Uses & Indications
Dosage
Adults
Apply a small amount of ointment or cream to the affected area two to three times daily for 5-10 days. For nasal ointment, apply a small amount into each nostril two times daily for 5 days.
Elderly
No dosage adjustment is required for elderly patients.
Renal_impairment
No dosage adjustment is required for patients with renal impairment as systemic absorption is minimal.
How to Take
Wash hands before and after applying the medicine. Apply a thin layer to the affected area. The treated area may be covered with a sterile gauze dressing if desired.
Mechanism of Action
Mupirocin inhibits bacterial protein synthesis by reversibly binding to bacterial isoleucyl-tRNA synthetase, thereby preventing the incorporation of isoleucine into bacterial proteins.
Pharmacokinetics
Onset
Clinical improvement typically seen within 3-5 days.
Excretion
Excreted renally as monic acid.
Half life
Systemic half-life is short (20-40 minutes) for absorbed drug.
Absorption
Minimal systemic absorption (less than 0.2%) after topical application to intact or damaged skin. Nasal absorption is also very low.
Metabolism
Rapidly metabolized to an inactive metabolite, monic acid, in the skin and systemically.
Side Effects
Contraindications
- Hypersensitivity to mupirocin or any of the excipients.
- Not for ophthalmic or intranasal use if formulation is not specifically for it.
Drug Interactions
Chloramphenicol
Incompatible with mupirocin due to potential antagonism. Do not use concomitantly.
Storage
Store below 25-30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Overdose with topical mupirocin is highly unlikely due to minimal systemic absorption. In case of accidental ingestion, supportive care is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. It is not known whether mupirocin is excreted in human milk. Exercise caution when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to mupirocin or any of the excipients.
- Not for ophthalmic or intranasal use if formulation is not specifically for it.
Drug Interactions
Chloramphenicol
Incompatible with mupirocin due to potential antagonism. Do not use concomitantly.
Storage
Store below 25-30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Overdose with topical mupirocin is highly unlikely due to minimal systemic absorption. In case of accidental ingestion, supportive care is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. It is not known whether mupirocin is excreted in human milk. Exercise caution when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months, varies by manufacturer and formulation.
Availability
Available in pharmacies
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied and clinically proven for the treatment of various bacterial skin infections. Ongoing trials may focus on new formulations or resistance patterns.
Lab Monitoring
- No specific laboratory monitoring is generally required for topical mupirocin.
Doctor Notes
- Emphasize the importance of completing the full course of treatment to prevent recurrence and resistance.
- Advise patients on proper hygiene practices.
- Monitor for signs of superinfection or persistent irritation.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve.
- Avoid getting the medicine in your eyes. If it gets into your eyes, rinse thoroughly with water.
- Do not ingest the medicine.
- Avoid using other topical preparations on the same area unless advised by a doctor.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose.
Driving Precautions
Mupirocin topical application is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good personal hygiene to prevent the spread of infection.
- Avoid sharing towels and personal items to prevent transmission of bacteria.
- Keep the affected area clean and dry.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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