Mupiskin
Generic Name
Mupirocin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mupiskin 2 w ointment | ৳ 180.00 | N/A |
Description
Overview of the medicine
Mupiskin Ointment is a topical antibiotic used to treat bacterial skin infections such as impetigo, folliculitis, and furunculosis. It is effective against various Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA).
Uses & Indications
Dosage
Adults
Apply a small amount to the affected area three times daily for 3-10 days, or as directed by physician.
Elderly
No special dosage adjustment required for topical application.
Renal_impairment
No special dosage adjustment required for topical application due to minimal systemic absorption.
How to Take
For external use only. Wash hands before and after application. Apply a thin layer to cover the affected skin area. The treated area may be covered with a sterile dressing.
Mechanism of Action
Mupirocin inhibits bacterial protein synthesis by reversibly binding to bacterial isoleucyl-tRNA synthetase, an enzyme necessary for the synthesis of bacterial proteins.
Pharmacokinetics
Onset
Clinical improvement usually seen within 3-5 days.
Excretion
Excreted renally as monic acid.
Half life
Systemic half-life is 20-40 minutes (when absorbed) and is rapidly metabolized.
Absorption
Minimal systemic absorption through intact skin. Absorption may be increased through damaged skin.
Metabolism
Rapidly metabolized to an inactive metabolite, monic acid, in the skin and systemically.
Side Effects
Contraindications
- Hypersensitivity to mupirocin or any component of the formulation
- Not for ophthalmic or intranasal use (except nasal formulation)
- Do not use in extensive burns or open wounds due to potential systemic absorption of polyethylene glycol
Drug Interactions
No significant interactions
No significant systemic drug interactions are expected with topical mupirocin due to its minimal absorption. However, avoid co-administration with other topical products on the same area without medical advice.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children. Discard any unused portion after the treatment course is completed.
Overdose
Overdose with topical application is unlikely due to minimal systemic absorption. If accidentally ingested, symptomatic treatment may be required. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use in pregnancy only if clearly needed. Excretion into breast milk is unknown, but systemic absorption is minimal, making adverse effects in breastfed infants unlikely.
Side Effects
Contraindications
- Hypersensitivity to mupirocin or any component of the formulation
- Not for ophthalmic or intranasal use (except nasal formulation)
- Do not use in extensive burns or open wounds due to potential systemic absorption of polyethylene glycol
Drug Interactions
No significant interactions
No significant systemic drug interactions are expected with topical mupirocin due to its minimal absorption. However, avoid co-administration with other topical products on the same area without medical advice.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children. Discard any unused portion after the treatment course is completed.
Overdose
Overdose with topical application is unlikely due to minimal systemic absorption. If accidentally ingested, symptomatic treatment may be required. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use in pregnancy only if clearly needed. Excretion into breast milk is unknown, but systemic absorption is minimal, making adverse effects in breastfed infants unlikely.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, refer to product packaging for specific dates.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated Mupirocin's efficacy and safety in treating various bacterial skin infections, including impetigo and secondary infected dermatoses.
Lab Monitoring
- No specific lab monitoring required for topical use. Cultures may be taken to confirm bacterial infection and susceptibility.
Doctor Notes
- Advise patients on proper application technique and the importance of completing the full course.
- Monitor for signs of superinfection or lack of clinical response, which may indicate resistant organisms.
- Avoid use in extensive burns or open wounds where systemic absorption of polyethylene glycol may occur.
- Consider nasal mupirocin for S. aureus decolonization where appropriate.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve to prevent recurrence.
- Avoid contact with eyes, and if it occurs, rinse thoroughly with water.
- Do not use for longer than prescribed to avoid overgrowth of resistant organisms.
- Inform your doctor if there is no improvement after 3-5 days of treatment.
Missed Dose Advice
Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not apply extra to make up for a missed dose.
Driving Precautions
Mupirocin topical has no known systemic effects that would impair the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good personal hygiene to prevent the spread of infection and reinfection.
- Avoid sharing towels, flannels, or other personal items with others.
- Keep the affected area clean and dry.
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Global Brand Names
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