Mycofree-OC
Generic Name
Ofloxacin + Ornidazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mycofree oc 005 075 cream | ৳ 150.00 | N/A |
Description
Overview of the medicine
Mycofree-OC is a combination antibiotic used to treat various bacterial and parasitic infections. It contains Ofloxacin, a fluoroquinolone antibiotic, and Ornidazole, a nitroimidazole antiprotozoal agent, providing broad-spectrum coverage.
Uses & Indications
Dosage
Adults
Typically one tablet (Ofloxacin 200 mg + Ornidazole 500 mg) twice daily for 5-7 days, or as directed by physician.
Elderly
Dosage adjustment may be required in elderly patients, especially with renal impairment.
Renal_impairment
Reduced dosage required for patients with creatinine clearance < 50 mL/min.
How to Take
Take orally with or without food. Complete the full course of treatment as prescribed.
Mechanism of Action
Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential for bacterial DNA replication, transcription, repair, and recombination. Ornidazole causes DNA damage and inhibits nucleic acid synthesis in anaerobic bacteria and protozoa.
Pharmacokinetics
Onset
Varies by infection type, generally within hours to days for symptom improvement.
Excretion
Primarily excreted via the kidneys.
Half life
Ofloxacin: approximately 4-6 hours; Ornidazole: approximately 12-14 hours.
Absorption
Both Ofloxacin and Ornidazole are well absorbed orally.
Metabolism
Ofloxacin is minimally metabolized. Ornidazole is extensively metabolized in the liver.
Side Effects
Contraindications
- •Hypersensitivity to Ofloxacin, Ornidazole, or other quinolones/nitroimidazoles
- •Epilepsy or history of seizures
- •First trimester of pregnancy
Drug Interactions
Alcohol
Disulfiram-like reaction with Ornidazole (though less severe than Metronidazole).
Warfarin
May enhance anticoagulant effect.
Antacids/Iron/Zinc
Reduced absorption of Ofloxacin if taken concomitantly.
Cimetidine/Phenobarbital
May affect Ornidazole metabolism.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptoms may include nausea, vomiting, dizziness, headache, confusion, seizures. Management involves symptomatic and supportive care.
Pregnancy & Lactation
Contraindicated in the first trimester of pregnancy. Use with caution in later trimesters only if clearly needed. Not recommended during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA in Bangladesh
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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