Mycorest
Generic Name
Fluconazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mycorest 50 mg capsule | ৳ 6.00 | N/A |
Description
Overview of the medicine
Mycorest (Fluconazole) is an antifungal medication used to treat various fungal infections, including vaginal candidiasis, oral thrush, esophageal candidiasis, and systemic candidiasis. It works by inhibiting the growth of fungi.
Uses & Indications
Dosage
Adults
For vaginal candidiasis: 150 mg oral single dose. For other infections, dosage varies (e.g., 50-400 mg daily).
Elderly
No dosage adjustment needed unless renal impairment present.
Renal_impairment
Dosage adjustment required based on creatinine clearance.
How to Take
Oral administration, can be taken with or without food.
Mechanism of Action
Fluconazole inhibits fungal cytochrome P450 enzyme 14-alpha-demethylase, which is essential for the synthesis of ergosterol, a vital component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to increased fungal cell membrane permeability and cell death.
Pharmacokinetics
Onset
Clinical effects usually within 24-48 hours, but can vary based on infection.
Excretion
Primarily excreted unchanged in urine.
Half life
Approximately 30 hours.
Absorption
Well absorbed orally, bioavailability >90%.
Metabolism
Minimal hepatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to fluconazole or other azole antifungals
- Co-administration with terfenadine, cisapride, astemizole, pimozide, quinidine, or erythromycin
Drug Interactions
Warfarin
Increased prothrombin time, risk of bleeding.
Phenytoin
Increased phenytoin levels, toxicity risk.
Rifampicin
Decreased fluconazole plasma concentrations.
Oral Hypoglycemics
Increased hypoglycemic effect, monitor blood glucose.
Storage
Store at room temperature, away from light and moisture.
Overdose
Gastric lavage, symptomatic and supportive treatment. Hemodialysis significantly decreases plasma levels.
Pregnancy & Lactation
Not recommended in pregnancy, especially in the first trimester, unless benefits outweigh risks. Caution in lactation, fluconazole is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to package for exact date.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established its efficacy and safety for approved indications.
Lab Monitoring
- Liver function tests (especially with prolonged use)
- Renal function tests
Doctor Notes
- Monitor liver function tests, especially in patients with pre-existing hepatic impairment or during prolonged treatment.
- Caution with co-administration of drugs that prolong QT interval.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve.
- Inform your doctor about all other medications you are taking.
- Seek medical attention if severe side effects occur.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness, so caution is advised when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent recurrence of fungal infections.
- Avoid sharing personal items like towels or clothing.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.