Mydipin
Generic Name
Amlodipine Besilate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mydipin 10 mg tablet | ৳ 9.00 | ৳ 126.00 |
Description
Overview of the medicine
Mydipin 10 mg tablet contains Amlodipine, a calcium channel blocker. It is used to treat high blood pressure (hypertension) and chest pain (angina).
Uses & Indications
Dosage
Adults
Initial dose is 5 mg once daily, which may be increased to a maximum of 10 mg once daily, depending on the patient's response and tolerability.
Elderly
No dosage adjustment required, but close monitoring is advised, as clearance may be reduced.
Renal_impairment
No dosage adjustment is necessary.
How to Take
Take orally once daily, with or without food, at approximately the same time each day.
Mechanism of Action
Amlodipine works by relaxing blood vessels, which lowers blood pressure and improves blood flow to the heart.
Pharmacokinetics
Onset
6-12 hours (for blood pressure lowering effect)
Excretion
Excreted primarily in the urine (approximately 60% as metabolites and 10% as unchanged drug).
Half life
30-50 hours
Absorption
Well-absorbed orally, with peak plasma concentrations occurring 6-12 hours post-dose. Bioavailability is 64-90%.
Metabolism
Extensively metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to amlodipine or other dihydropyridines
- •Severe hypotension
- •Cardiogenic shock
- •Significant aortic stenosis
- •Unstable angina (unless in a hospital setting)
Drug Interactions
Simvastatin
Limit simvastatin dose to 20 mg/day when co-administered with amlodipine.
CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir)
May increase amlodipine exposure, requiring dose reduction.
CYP3A4 Inducers (e.g., rifampicin, St. John's Wort)
May decrease amlodipine plasma concentrations.
Storage
Store at room temperature (below 25°C), protected from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to excessive peripheral vasodilation with marked hypotension and possibly reflex tachycardia. Management involves supportive measures, including monitoring of cardiac and respiratory function, elevation of extremities, and administration of IV fluids.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Small amounts excreted in breast milk; caution advised for nursing mothers. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the date of manufacture, specific to batch.
Availability
Pharmacies and Hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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