Mydri-Atropine
Generic Name
Atropine Sulfate Ophthalmic Ointment 1%
Manufacturer
Various Pharmaceutical Companies
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mydri atropine 1 eye ointment | ৳ 25.00 | N/A |
Description
Overview of the medicine
Atropine ophthalmic ointment is an anticholinergic agent used to dilate pupils (mydriasis) and paralyze the ciliary muscle (cycloplegia) for ophthalmic examinations and treatment of certain eye conditions.
Uses & Indications
Dosage
Adults
For cycloplegic refraction: Apply a 1/2 inch strip of ointment in the conjunctival sac 3 times daily for 1-3 days prior to examination. For uveitis: 1/2 inch strip 1-3 times daily, or as directed by physician.
Elderly
Similar to adults, but use with caution due to increased risk of systemic absorption and sensitivity.
Renal_impairment
No specific dosage adjustment for ocular use; however, monitor for systemic anticholinergic effects if significant absorption occurs.
How to Take
Wash hands thoroughly before and after use. Gently pull down the lower eyelid to form a pocket. Apply a small amount (about 1/2 inch strip) of ointment into the conjunctival sac. Close the eye gently for 1-2 minutes. Apply pressure to the nasolacrimal duct (inner corner of the eye) to reduce systemic absorption. Do not touch the tip of the tube to the eye or any other surface.
Mechanism of Action
Atropine blocks the action of acetylcholine at muscarinic receptors in the iris and ciliary body, leading to mydriasis and cycloplegia.
Pharmacokinetics
Onset
Mydriasis usually within 30-40 minutes, cycloplegia within 1-3 hours.
Excretion
Primarily excreted unchanged in urine.
Half life
Ocular effects can last for several days (up to 2 weeks). Systemic half-life is about 2-4 hours.
Absorption
Well-absorbed systemically through the conjunctiva; systemic absorption can occur.
Metabolism
Partially metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to atropine or any component of the formulation.
- Primary glaucoma or a tendency toward narrow-angle glaucoma.
- Children with Down's syndrome, spastic paralysis, or brain damage due to increased susceptibility to systemic toxicity.
Drug Interactions
Other Anticholinergics
Concurrent use may increase systemic anticholinergic effects.
Monoamine Oxidase Inhibitors (MAOIs)
Potential for increased systemic effects.
Storage
Store at controlled room temperature (15-30°C). Do not freeze. Keep the tube tightly closed when not in use. Protect from light.
Overdose
Systemic overdose symptoms include dry mouth, blurred vision, tachycardia, fever, urinary retention, central nervous system excitement, hallucinations, and delirium. Treatment is symptomatic and supportive; physostigmine may be used as an antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Atropine is excreted in breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to atropine or any component of the formulation.
- Primary glaucoma or a tendency toward narrow-angle glaucoma.
- Children with Down's syndrome, spastic paralysis, or brain damage due to increased susceptibility to systemic toxicity.
Drug Interactions
Other Anticholinergics
Concurrent use may increase systemic anticholinergic effects.
Monoamine Oxidase Inhibitors (MAOIs)
Potential for increased systemic effects.
Storage
Store at controlled room temperature (15-30°C). Do not freeze. Keep the tube tightly closed when not in use. Protect from light.
Overdose
Systemic overdose symptoms include dry mouth, blurred vision, tachycardia, fever, urinary retention, central nervous system excitement, hallucinations, and delirium. Treatment is symptomatic and supportive; physostigmine may be used as an antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Atropine is excreted in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years unopened. Discard 28 days after opening.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Atropine has been used for ophthalmic purposes for a very long time, and its efficacy and safety are well-established through extensive clinical experience and historical studies. New large-scale clinical trials are not typically conducted for this generic formulation.
Lab Monitoring
- None routinely required for ocular use. Monitor vital signs and mental status if systemic toxicity is suspected, especially in pediatric patients.
Doctor Notes
- Counsel patients on proper administration technique to minimize systemic absorption.
- Advise patients about prolonged effects on vision and light sensitivity.
- Exercise caution in patients with cardiac disease, prostatic hypertrophy, or Down's syndrome due to increased susceptibility to systemic anticholinergic effects.
Patient Guidelines
- Avoid driving or operating machinery until your vision clears and light sensitivity subsides.
- Wear sunglasses outdoors to protect your eyes from bright light due to pupil dilation.
- Do not wear contact lenses during treatment or for the duration of pupil dilation.
- Inform your doctor about any other eye conditions or medications you are using.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember, unless it is almost time for your next dose. Do not double the dose to catch up.
Driving Precautions
Atropine eye ointment causes significant and prolonged blurred vision and photophobia (light sensitivity). Patients should be advised not to drive or engage in hazardous activities until these effects have completely resolved.
Lifestyle Advice
- Avoid direct sunlight immediately after application.
- Maintain good eye hygiene to prevent infection.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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