Myocard
Generic Name
Metoprolol Succinate 25 mg
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| myocard 25 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Myocard 25 mg Tablet contains Metoprolol Succinate, an extended-release beta-blocker used to treat high blood pressure, angina pectoris, heart failure, and to prevent migraine headaches. It works by relaxing blood vessels and slowing the heart rate, improving blood flow and reducing blood pressure.
Uses & Indications
Dosage
Adults
Initial dose for hypertension/angina: 25-100 mg once daily, adjusted based on response up to 400 mg/day. For heart failure: Initial 12.5-25 mg once daily, titrated slowly to target dose.
Elderly
Similar to adults, but initial dose may be lower and titration more gradual due to potential reduced renal/hepatic function.
Renal_impairment
No dosage adjustment usually needed for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
Take orally, once daily, preferably in the morning, with or without food. Swallow the tablet whole; do not chew or crush it.
Mechanism of Action
Metoprolol Succinate is a cardioselective beta-1 adrenergic receptor blocker. It selectively blocks beta-1 receptors primarily found in the heart, leading to decreased heart rate, myocardial contractility, and cardiac output. It also reduces renin release from the kidneys.
Pharmacokinetics
Onset
Onset of action for blood pressure lowering is usually within 1 hour; full effect seen within 1 week of regular dosing.
Excretion
Excreted mainly via urine as metabolites; a small amount excreted unchanged.
Half life
Plasma half-life is 3-7 hours for metoprolol succinate, allowing once-daily dosing.
Absorption
Well absorbed from the GI tract; bioavailability is about 50% due to first-pass metabolism. Extended-release formulation provides steady plasma concentrations.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6, to inactive metabolites.
Side Effects
Contraindications
- •Severe bradycardia (heart rate < 45-50 bpm)
- •Sick sinus syndrome (unless permanent pacemaker is in place)
- •Second- or third-degree atrioventricular block
- •Decompensated heart failure
- •Cardiogenic shock
- •Severe peripheral arterial disease
- •Hypersensitivity to metoprolol or other beta-blockers
Drug Interactions
Digoxin
Increased risk of bradycardia and AV block. Monitor heart rate.
Clonidine
If clonidine is discontinued, beta-blocker should be tapered gradually before clonidine withdrawal to prevent rebound hypertension.
MAO Inhibitors
Concurrent use may result in significant hypertension or bradycardia.
NSAIDs (e.g., Ibuprofen)
May reduce the antihypertensive effect of metoprolol.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia, hypotension, and heart block. Monitor closely.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe bradycardia, hypotension, cardiac insufficiency, bronchospasm, and cardiac arrest. Treatment involves symptomatic and supportive measures, including atropine for bradycardia, vasopressors for hypotension, and glucagon or intravenous fluids as needed.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Metoprolol is excreted in breast milk; caution should be exercised when administered to a nursing mother. Monitor infants for signs of beta-blockade.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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