Myocard
Generic Name
Carvedilol
Manufacturer
Reputable Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| myocard 5 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Carvedilol is a non-selective beta-adrenergic blocker with alpha-1 blocking activity, used to treat hypertension, chronic stable angina, and heart failure.
Uses & Indications
Dosage
Adults
Hypertension: Initial 6.25 mg twice daily, increasing to 12.5 mg or 25 mg twice daily. Heart Failure: Initial 3.125 mg twice daily, gradually increasing every 2 weeks to a maximum of 25 mg twice daily (for patients <85 kg) or 50 mg twice daily (for patients >85 kg).
Elderly
No specific dosage adjustment usually required, but dose titration should be done carefully.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
Take orally with food to reduce the risk of orthostatic hypotension.
Mechanism of Action
Carvedilol reduces heart rate, myocardial contractility, and blood pressure by blocking beta-1, beta-2, and alpha-1 adrenergic receptors. Its alpha-1 blocking activity causes peripheral vasodilation, reducing peripheral vascular resistance.
Pharmacokinetics
Onset
Within 1 hour (blood pressure lowering effect), 1-2 weeks for full therapeutic effect in heart failure.
Excretion
Primarily excreted in the feces via bile; a small amount is excreted in the urine.
Half life
Approximately 7-10 hours.
Absorption
Rapidly and extensively absorbed after oral administration, with peak plasma concentrations occurring within 1-2 hours. Bioavailability is approximately 25-35% due to extensive first-pass metabolism.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 and CYP2C9, into several active and inactive metabolites.
Side Effects
Contraindications
- •Known hypersensitivity to carvedilol or any component of the formulation
- •Decompensated heart failure requiring intravenous inotropic therapy
- •Bronchial asthma or related bronchospastic conditions
- •Second- or third-degree AV block (unless a permanent pacemaker is in place)
- •Severe bradycardia (heart rate <50 bpm)
- •Cardiogenic shock
- •Severe hepatic impairment
Drug Interactions
Digoxin
Increased digoxin levels and additive bradycardia.
Rifampin
Reduced carvedilol plasma concentrations.
Cimetidine
Increased carvedilol bioavailability.
Insulin/Oral Hypoglycemics
May mask symptoms of hypoglycemia and potentiate the hypoglycemic effect.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of AV block, bradycardia, or heart failure.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe hypotension, bradycardia, heart failure, cardiogenic shock, and bronchospasm. Treatment involves supportive measures, including atropine for bradycardia, vasopressors for hypotension, and bronchodilators for bronchospasm.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding due to potential for adverse effects on the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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