Myorel
Generic Name
Tolperisone Hydrochloride
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| myorel 5 mg tablet | ৳ 5.50 | ৳ 55.00 |
Description
Overview of the medicine
Myorel 5 mg Tablet contains Tolperisone Hydrochloride, a centrally acting muscle relaxant. It is used to relieve muscle spasms and associated pain due to neurological conditions or musculoskeletal disorders. Please note that 5 mg is an unusually low strength for Tolperisone Hydrochloride; common therapeutic strengths are typically 50 mg or 150 mg. Consult a healthcare professional for appropriate dosing and to confirm the suitability of this strength for your condition.
Uses & Indications
Dosage
Adults
The typical therapeutic dose for Tolperisone is 50 mg to 150 mg, two to three times daily. A 5 mg dose is significantly lower than the standard therapeutic range for Tolperisone and its efficacy at this strength for muscle relaxation is questionable. Consult your physician for appropriate dosing based on your specific condition and the actual therapeutic strength required.
Elderly
No specific dose adjustment is generally required, but caution is advised in elderly patients. Start with a lower dose if necessary and monitor for adverse effects.
Renal_impairment
Dose adjustment may be necessary in patients with moderate to severe renal impairment. Careful monitoring is recommended.
How to Take
Orally, with a small amount of liquid, preferably after meals to reduce gastrointestinal irritation and improve bioavailability.
Mechanism of Action
Tolperisone acts on the central nervous system, primarily by stabilizing neuronal membranes and reducing the excitability of motor neurons. It inhibits voltage-gated sodium and calcium channels, leading to a reduction in polysynaptic and monosynaptic reflex activity. It does not directly depress the central nervous system, thus avoiding sedative effects common with other muscle relaxants.
Pharmacokinetics
Onset
Typically within 1 hour after oral administration.
Excretion
Primarily excreted via the kidneys (over 99%) as metabolites.
Half life
Approximately 1.5-2.5 hours.
Absorption
Well absorbed from the gastrointestinal tract, but undergoes extensive first-pass metabolism. Bioavailability is approximately 17%. Peak plasma concentrations within 0.5-1.5 hours.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (mainly CYP2D6) and non-CYP pathways.
Side Effects
Contraindications
- •Hypersensitivity to Tolperisone or any component of the tablet
- •Myasthenia gravis
- •Children (due to insufficient data, especially for 5 mg strength)
Drug Interactions
Other centrally acting muscle relaxants
May potentiate the effects of Tolperisone. Co-administration should be with caution.
Drugs metabolized by CYP2D6 (e.g., Thioridazine, Tolterodine, Venlafaxine, Atomoxetine, Dextromethorphan, Metoprolol, Nebivolol, Perphenazine)
Tolperisone may increase the plasma levels of these drugs due to moderate CYP2D6 inhibition. Close monitoring and dose adjustment may be necessary.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, gastrointestinal upset, and in severe cases, central nervous system depression. Treatment is symptomatic and supportive. Gastric lavage may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is unknown if it is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Available in pharmacies
Approval Status
Approved in many countries (e.g., Bangladesh, India, Europe)
Patent Status
Off-patent
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Global Brand Names
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