Myoson
Generic Name
Tolperisone Hydrochloride
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| myoson 100 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Myoson 100 mg Tablet contains Tolperisone Hydrochloride, a centrally acting muscle relaxant used to treat increased tone of skeletal muscles due to neurological disorders or musculoskeletal conditions.
Uses & Indications
Dosage
Adults
Usually 50-150 mg three times daily, depending on individual response and tolerability. Starting dose often 50 mg three times daily, increasing gradually.
Elderly
No specific dose adjustment generally required, but caution is advised.
Renal_impairment
Caution advised, dosage reduction may be necessary in severe renal impairment.
How to Take
Oral. Taken with food to increase bioavailability and reduce gastrointestinal upset. Swallow whole with a glass of water.
Mechanism of Action
Tolperisone acts on the central nervous system to reduce muscle tone without causing sedation. It primarily acts on the spinal cord by inhibiting voltage-gated sodium and calcium channels, which leads to a decrease in the release of excitatory neurotransmitters.
Pharmacokinetics
Onset
Rapid, generally within an hour.
Excretion
Primarily via the kidneys as metabolites.
Half life
Approximately 1.5 to 2.5 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 0.5-1.5 hours.
Metabolism
Extensively metabolized in the liver (primarily via CYP2B6, CYP2D6, CYP1A2, CYP3A4) and kidneys.
Side Effects
Contraindications
- Hypersensitivity to Tolperisone or chemically similar eperisone
- Myasthenia gravis
- Children below 18 years (limited data)
Drug Interactions
Alcohol
Does not increase the sedative effect of alcohol.
Methocarbamol
Increased risk of adverse effects when co-administered.
Other centrally acting muscle relaxants
Potentiation of effects, caution advised.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, gastrointestinal disturbances, and rarely, seizures. Treatment is symptomatic and supportive. Gastric lavage may be considered.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the first trimester, due to limited data. Use only if potential benefit outweighs risk. Excretion into breast milk is unknown, therefore not recommended during lactation.
Side Effects
Contraindications
- Hypersensitivity to Tolperisone or chemically similar eperisone
- Myasthenia gravis
- Children below 18 years (limited data)
Drug Interactions
Alcohol
Does not increase the sedative effect of alcohol.
Methocarbamol
Increased risk of adverse effects when co-administered.
Other centrally acting muscle relaxants
Potentiation of effects, caution advised.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, gastrointestinal disturbances, and rarely, seizures. Treatment is symptomatic and supportive. Gastric lavage may be considered.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the first trimester, due to limited data. Use only if potential benefit outweighs risk. Excretion into breast milk is unknown, therefore not recommended during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated its efficacy and safety in reducing muscle spasticity and associated symptoms.
Lab Monitoring
- No specific routine lab monitoring is generally required. Liver and kidney function tests may be considered in patients with pre-existing conditions.
Doctor Notes
- Advise patients on potential dizziness/drowsiness. Emphasize importance of taking with food to improve absorption and reduce GI side effects. Monitor for hypersensitivity reactions.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine abruptly.
- Report any unusual side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness in some individuals. Exercise caution when driving or operating machinery until you know how Myoson affects you.
Lifestyle Advice
- Maintain a healthy lifestyle with regular exercise if appropriate.
- Avoid activities requiring mental alertness until you know how the medicine affects you.
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Global Brand Names
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