Myoson
Generic Name
Tolperisone Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| myoson 50 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Myoson 50 mg Tablet contains Tolperisone Hydrochloride, a centrally acting muscle relaxant used to treat pathological hypertonus of striated muscle due to neurological diseases (e.g., multiple sclerosis, myelopathy, encephalomyelitis) and in spasticity following stroke, as well as musculoskeletal disorders (e.g., spondylosis, spondylarthrosis, lumbago, cervicobrachial syndrome).
Uses & Indications
Dosage
Adults
Usually 50-150 mg three times daily, depending on individual need and tolerability.
Elderly
Dosage should be individualized, starting with a lower dose and carefully monitoring for adverse effects.
Renal_impairment
Severe renal impairment: Not recommended. Moderate renal impairment: Dosage reduction required, individual titration.
How to Take
To be taken orally, preferably after meals, with a glass of water.
Mechanism of Action
Tolperisone acts on the central nervous system. It primarily reduces muscle tone by inhibiting voltage-gated sodium and calcium channels, which in turn decreases the release of excitatory neurotransmitters from the primary afferent nerve endings. It also has a weak alpha-adrenergic blocking effect. It does not cause sedation.
Pharmacokinetics
Onset
Within 1 hour.
Excretion
Excreted primarily via the kidneys as metabolites.
Half life
Approximately 1.5-2.5 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract. Peak plasma concentration reached within 0.5-1.5 hours after oral administration. Undergoes extensive first-pass metabolism.
Metabolism
Extensively metabolized in the liver and kidneys, primarily by CYP2D6 and other enzymes.
Side Effects
Contraindications
- Hypersensitivity to Tolperisone or any component of the formulation.
- Myasthenia gravis.
- Children and adolescents (due to lack of sufficient data).
Drug Interactions
Methocarbamol
May increase the effect of Tolperisone.
CYP2D6 substrates
Tolperisone is a mild inhibitor of CYP2D6, so caution with drugs metabolized by CYP2D6 (e.g., thioridazine, tolterodine, venlafaxine, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine).
Other centrally acting muscle relaxants
Caution advised as their effects may be additive.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, gastrointestinal symptoms (e.g., nausea, vomiting, epigastric pain), and in severe cases, convulsions. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is unknown if it is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Tolperisone or any component of the formulation.
- Myasthenia gravis.
- Children and adolescents (due to lack of sufficient data).
Drug Interactions
Methocarbamol
May increase the effect of Tolperisone.
CYP2D6 substrates
Tolperisone is a mild inhibitor of CYP2D6, so caution with drugs metabolized by CYP2D6 (e.g., thioridazine, tolterodine, venlafaxine, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine).
Other centrally acting muscle relaxants
Caution advised as their effects may be additive.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, gastrointestinal symptoms (e.g., nausea, vomiting, epigastric pain), and in severe cases, convulsions. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is unknown if it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved in many countries
Patent Status
Off-patent
Clinical Trials
Tolperisone has been studied in various clinical trials for its efficacy and safety in muscle spasticity and musculoskeletal pain. Research has focused on its non-sedative properties compared to other muscle relaxants.
Lab Monitoring
- No routine lab monitoring is specifically required. Liver function tests may be considered in patients with pre-existing hepatic impairment or during prolonged treatment.
Doctor Notes
- Emphasize its non-sedative nature, which is beneficial for patients requiring alertness.
- Advise patients to take it after meals to enhance absorption and reduce GI side effects.
- Monitor for allergic reactions, especially skin rashes, which are the most common hypersensitivity reactions.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
- If you experience any allergic reactions, seek medical attention immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or somnolence in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Avoid alcohol consumption as it may increase side effects.
- Engage in physical therapy as recommended by your doctor.
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