Myrox SR
Generic Name
Mirtazapine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| myrox sr 75 mg capsule | ৳ 5.04 | ৳ 50.40 |
Description
Overview of the medicine
Myrox SR contains Mirtazapine, an antidepressant used to treat major depressive disorder. The SR (sustained-release) formulation provides a prolonged therapeutic effect.
Uses & Indications
Dosage
Adults
Typically, initial dose is 15 mg once daily, preferably in the evening. May be increased up to a maximum of 45 mg daily based on response.
Elderly
Lower initial dose (e.g., 7.5 mg) and careful titration are recommended due to potential for reduced clearance and increased sensitivity.
Renal_impairment
Dose adjustment required. For severe renal impairment, consider a 50% dose reduction.
How to Take
Take orally once daily, preferably in the evening before bedtime. Swallow the tablet whole; do not crush, chew, or divide.
Mechanism of Action
Mirtazapine works by increasing the activity of certain neurotransmitters in the brain, such as norepinephrine and serotonin. It blocks alpha-2 adrenergic presynaptic receptors and 5-HT2 and 5-HT3 receptors.
Pharmacokinetics
Onset
Therapeutic effects may take 1-2 weeks; sleep improvement may be seen earlier.
Excretion
Primarily via urine (approximately 75%) and feces (approximately 15%).
Half life
20-40 hours (average 26 hours), allowing for once-daily dosing.
Absorption
Rapidly absorbed after oral administration; sustained-release formulation provides prolonged absorption. Peak plasma concentrations reached within hours.
Metabolism
Extensively metabolized in the liver by CYP1A2, CYP2D6, and CYP3A4 enzymes.
Side Effects
Contraindications
- •Hypersensitivity to Mirtazapine or any excipients
- •Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI
Drug Interactions
MAOIs
Risk of serotonin syndrome. Avoid concomitant use.
Warfarin
May increase prothrombin time and INR; monitor coagulation parameters.
SSRIs, SNRIs, Triptans
Increased risk of serotonin syndrome.
CYP inhibitors (e.g., ketoconazole, cimetidine)
May increase Mirtazapine plasma levels. Dose adjustment may be necessary.
CNS Depressants (e.g., alcohol, benzodiazepines)
Increased CNS depressant effects. Avoid concomitant use.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, disorientation, tachycardia, impaired consciousness, and possibly mild hypertension or hypotension. Treatment is symptomatic and supportive; no specific antidote. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Limited data suggest excretion into breast milk; use with caution and monitor the infant for adverse effects during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent (generic available)
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Global Brand Names
International brand names for this medicine
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