Nabu
Generic Name
Naproxen 500 mg tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nabu 500 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Nabu 500 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and stiffness caused by conditions such as arthritis, menstrual pain, and muscle aches. It works by blocking the body's production of certain natural substances that cause inflammation.
Uses & Indications
Dosage
Adults
500 mg twice daily, or 500 mg initially followed by 250 mg every 6-8 hours as needed, not exceeding 1250 mg on the first day and 1000 mg daily thereafter. For acute gout, 750 mg initially, then 250 mg every 8 hours until the attack subsides.
Elderly
Use the lowest effective dose for the shortest possible duration. Monitor for adverse effects, especially GI bleeding and renal impairment.
Renal_impairment
Not recommended in patients with severe renal impairment (creatinine clearance <30 mL/min). Lower doses may be required for moderate impairment, with careful monitoring.
How to Take
Orally, with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a full glass of water. Do not crush, chew, or break.
Mechanism of Action
Naproxen works by reversibly inhibiting the cyclooxygenase (COX-1 and COX-2) enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins are mediators of inflammation, pain, and fever. By reducing prostaglandin synthesis, naproxen reduces inflammation, pain, and fever.
Pharmacokinetics
Onset
Within 1 hour for analgesia; up to 2 weeks for anti-inflammatory effects.
Excretion
Mainly excreted in the urine (approximately 95%) as naproxen, 6-O-desmethylnaproxen, and their conjugates. A small amount is excreted in feces.
Half life
Approximately 12-17 hours.
Absorption
Rapidly and completely absorbed from the GI tract after oral administration. Peak plasma concentrations are achieved within 2-4 hours.
Metabolism
Primarily metabolized in the liver by the cytochrome P450 system (CYP2C9) to 6-O-desmethylnaproxen, then extensively conjugated.
Side Effects
Contraindications
- Hypersensitivity to naproxen or other NSAIDs (e.g., aspirin-induced asthma, urticaria)
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe heart failure
- Severe renal impairment
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery
Drug Interactions
Lithium
Increased lithium plasma concentrations, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
ACE inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Other NSAIDs/Aspirin
Increased risk of GI side effects and bleeding.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects. Risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, heartburn, nausea, vomiting, epigastric pain, GI bleeding. Severe overdose may lead to renal dysfunction, hypotension, respiratory depression, and coma. Management is supportive; gastric lavage or activated charcoal may be considered if recent ingestion. Hemodialysis is not effective.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use only if clearly needed during first and second trimesters. Naproxen passes into breast milk; use with caution or consider alternatives during lactation.
Side Effects
Contraindications
- Hypersensitivity to naproxen or other NSAIDs (e.g., aspirin-induced asthma, urticaria)
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe heart failure
- Severe renal impairment
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery
Drug Interactions
Lithium
Increased lithium plasma concentrations, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
ACE inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Other NSAIDs/Aspirin
Increased risk of GI side effects and bleeding.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects. Risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, heartburn, nausea, vomiting, epigastric pain, GI bleeding. Severe overdose may lead to renal dysfunction, hypotension, respiratory depression, and coma. Management is supportive; gastric lavage or activated charcoal may be considered if recent ingestion. Hemodialysis is not effective.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use only if clearly needed during first and second trimesters. Naproxen passes into breast milk; use with caution or consider alternatives during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by FDA/DGDA
Patent Status
Patent expired, available generically
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of naproxen for various inflammatory and pain conditions. Ongoing research continues to explore its long-term effects and comparative effectiveness.
Lab Monitoring
- Complete Blood Count (CBC) (monitor for anemia)
- Liver function tests (LFTs)
- Kidney function tests (Serum Creatinine, BUN)
- Blood pressure monitoring
Doctor Notes
- Advise patients on GI and cardiovascular risks.
- Consider prophylactic PPI for high-risk patients.
- Monitor renal function, blood pressure, and CBC periodically, especially in elderly or long-term users.
- Educate on potential drug interactions.
Patient Guidelines
- Take with food or milk to reduce stomach upset.
- Do not exceed the prescribed dose.
- Avoid alcohol while taking this medicine.
- Report any signs of unusual bleeding, black stools, or severe stomach pain immediately.
- Inform your doctor about all other medications you are taking, especially blood thinners or other NSAIDs.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or drowsiness. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a healthy diet to support overall health.
- Engage in moderate exercise if appropriate for your condition.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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