Nabu
Generic Name
Nabumetone
Manufacturer
Reputable Pharmaceuticals Inc.
Country
Global
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nabu 750 mg tablet | ৳ 22.00 | ৳ 220.00 |
Description
Overview of the medicine
Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) used for the symptomatic treatment of osteoarthritis and rheumatoid arthritis. It provides pain relief and reduces inflammation.
Uses & Indications
Dosage
Adults
Usually 750-1500 mg once daily or in two divided doses. Maximum 2000 mg/day.
Elderly
Lower doses may be considered; monitor renal function.
Renal_impairment
Use with caution; dose adjustment may be necessary in severe impairment. Not recommended for severe renal impairment.
How to Take
Oral. Should be taken with food or milk to reduce gastrointestinal upset.
Mechanism of Action
Nabumetone is a prodrug that is metabolized to 6-methoxy-2-naphthylacetic acid (6-MNA), which is an active NSAID. It inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of pain and inflammation.
Pharmacokinetics
Onset
Clinical effects observed within 1-2 hours, peak effect usually by 4-6 hours.
Excretion
Primarily excreted in the urine as inactive metabolites and their conjugates, with a small amount in feces.
Half life
Active metabolite (6-MNA) has a half-life of 22-24 hours.
Absorption
Well absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized in the liver to the active metabolite 6-MNA and other inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to nabumetone or other NSAIDs
- Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
- Active gastrointestinal bleeding or peptic ulcer
- Severe hepatic or renal impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
Diuretics/ACE inhibitors
Reduced antihypertensive effect; increased risk of renal impairment.
Storage
Store below 30°C, in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain. Management is supportive; gastric lavage, activated charcoal may be considered. Monitor renal and hepatic function.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus. Use with caution in first and second trimesters. Excreted in breast milk, use with caution or avoid during lactation.
Side Effects
Contraindications
- Hypersensitivity to nabumetone or other NSAIDs
- Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
- Active gastrointestinal bleeding or peptic ulcer
- Severe hepatic or renal impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
Diuretics/ACE inhibitors
Reduced antihypertensive effect; increased risk of renal impairment.
Storage
Store below 30°C, in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain. Management is supportive; gastric lavage, activated charcoal may be considered. Monitor renal and hepatic function.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus. Use with caution in first and second trimesters. Excreted in breast milk, use with caution or avoid during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated Nabumetone's efficacy and safety in treating osteoarthritis and rheumatoid arthritis.
Lab Monitoring
- Regular monitoring of complete blood count (CBC), renal function (creatinine, BUN), and liver function (ALT, AST) is recommended during long-term therapy.
Doctor Notes
- Consider lowest effective dose for shortest duration.
- Monitor GI and cardiovascular risk factors.
- Caution in elderly and patients with pre-existing renal/hepatic impairment.
Patient Guidelines
- Take as directed, do not exceed recommended dose.
- Report any unusual bleeding, stomach pain, or dark stools.
- Avoid concomitant use with other NSAIDs or aspirin without consulting a doctor.
Missed Dose Advice
Take the missed dose as soon as remembered, unless it is almost time for the next dose. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness. Patients should be cautious when driving or operating machinery until they know how the drug affects them.
Lifestyle Advice
- Avoid alcohol.
- Maintain a balanced diet.
- Regular exercise as tolerated for arthritis management.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Nabu Brand
Other medicines available under the same brand name
