Nabumet
Generic Name
Nabumetone 1000 mg Tablet
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nabumet 1000 mg tablet | ৳ 30.00 | ৳ 180.00 |
Description
Overview of the medicine
Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and stiffness caused by osteoarthritis and rheumatoid arthritis. It is a prodrug that is converted in the liver to its active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA).
Uses & Indications
Dosage
Adults
The usual starting dose is 1000 mg once daily, taken as a single dose or 500 mg twice daily. The dose can be increased to 1500-2000 mg daily if needed. Maximum daily dose is 2000 mg.
Elderly
Use the lowest effective dose. Increased risk of adverse effects, particularly GI bleeding and renal impairment.
Renal_impairment
Caution is advised. Consider dose reduction in patients with severe renal impairment (creatinine clearance <30 mL/min).
How to Take
Oral administration. Take with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Nabumetone, a prodrug, is converted to 6-MNA, which inhibits cyclooxygenase (COX) enzymes (COX-1 and COX-2), thereby reducing prostaglandin synthesis. This reduction leads to anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics
Onset
Analgesic effect: 2-4 hours. Full anti-inflammatory effect: several days to 2 weeks.
Excretion
Primarily via urine as 6-MNA and its glucuronide conjugate.
Half life
Nabumetone: approximately 1 hour. Active metabolite (6-MNA): approximately 24 hours.
Absorption
Well absorbed from the GI tract after oral administration. Nabumetone itself is poorly absorbed; the prodrug is rapidly metabolized.
Metabolism
Nabumetone is a prodrug, extensively metabolized in the liver to its active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA).
Side Effects
Contraindications
- •Hypersensitivity to nabumetone or other NSAIDs
- •History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
- •In the setting of coronary artery bypass graft (CABG) surgery
- •Severe heart failure
- •Severe renal or hepatic impairment
- •Last trimester of pregnancy
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Methotrexate
May increase methotrexate plasma levels and toxicity.
Corticosteroids
Increased risk of gastrointestinal side effects.
Diuretics and ACE Inhibitors
May reduce the antihypertensive effect and increase the risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, and epigastric pain. Management is primarily supportive and symptomatic, and may include gastric lavage and activated charcoal if ingested recently.
Pregnancy & Lactation
Pregnancy Category C (Category D in the third trimester or near delivery). Avoid use in late pregnancy. Use with caution during lactation; small amounts may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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