Nabumet
Generic Name
Nabumetone 500 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nabumet 500 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) used for the symptomatic treatment of osteoarthritis and rheumatoid arthritis. It provides relief from pain, swelling, and stiffness by reducing inflammation.
Uses & Indications
Dosage
Adults
Usually 1000 mg orally once daily, as a single dose at bedtime or in two divided doses. May be increased to 1500-2000 mg daily if needed. For 500 mg tablet, one tablet twice daily or as directed by physician.
Elderly
Consider lower initial doses and closely monitor for adverse effects due to increased risk.
Renal_impairment
Use with caution, dose adjustment may be necessary. Avoid in severe renal impairment (CrCl <30 mL/min).
How to Take
Administer orally, with or without food. Taking with food may help reduce gastrointestinal upset.
Mechanism of Action
Nabumetone is a prodrug that is converted to its active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA), which inhibits cyclooxygenase (COX) enzymes, particularly COX-2, leading to decreased prostaglandin synthesis and subsequent anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics
Onset
Analgesic effect: 3-6 hours; Anti-inflammatory effect: days to weeks.
Excretion
Primarily excreted in the urine (around 75%) as metabolites and their conjugates; some fecal excretion.
Half life
Approximately 22-24 hours (for active metabolite 6-MNA).
Absorption
Well absorbed from the gastrointestinal tract, undergoes extensive first-pass metabolism to its active metabolite, 6-MNA. Food may increase absorption.
Metabolism
Extensively metabolized in the liver to its active metabolite 6-MNA and other inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to nabumetone or other NSAIDs
- •Active gastrointestinal bleeding or peptic ulcer disease
- •Severe renal or hepatic impairment
- •Severe heart failure
- •Third trimester of pregnancy
- •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels, leading to toxicity.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE Inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms: Drowsiness, lethargy, nausea, vomiting, epigastric pain, GI bleeding. Rare: hypertension, acute renal failure, respiratory depression, coma. Management: Gastric lavage or activated charcoal within one hour. Symptomatic and supportive treatment. Monitor renal function and electrolyte balance.
Pregnancy & Lactation
Pregnancy: Category C (first and second trimesters); Category D (third trimester). Avoid in the third trimester due to potential premature closure of the fetal ductus arteriosus. Lactation: Excreted in breast milk, not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies worldwide
Approval Status
Approved by DGDA
Patent Status
Patent Expired
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Global Brand Names
International brand names for this medicine
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