Nafex
Generic Name
Fexofenadine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nafex 120 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Nafex 120 mg Tablet contains Fexofenadine, a non-drowsy antihistamine used to relieve symptoms of seasonal allergic rhinitis (hay fever) and chronic idiopathic urticaria (hives). It helps alleviate symptoms like sneezing, runny nose, watery eyes, itchy eyes/nose/throat, and skin rash.
Uses & Indications
Dosage
Adults
The recommended dose for adults and children 12 years and older is 120 mg once daily.
Elderly
No dosage adjustment is generally required for elderly patients unless renal function is impaired.
Renal_impairment
For adult patients with impaired renal function, the recommended starting dose is 60 mg once daily.
How to Take
Take the tablet orally with water, preferably before a meal. Do not take with fruit juices (grapefruit, orange, apple) as they may reduce absorption.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist. It works by blocking histamine (a natural substance) that your body makes during an allergic reaction, thereby preventing the symptoms of allergy.
Pharmacokinetics
Onset
Onset of action is approximately 1 hour.
Excretion
Approximately 80% is excreted unchanged in the feces and 11% in the urine.
Half life
Elimination half-life is approximately 11 to 15 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached approximately 2-3 hours after a single dose.
Metabolism
Minimally metabolized (approximately 5% of a dose). Primarily metabolized in the liver.
Side Effects
Contraindications
- •Known hypersensitivity to Fexofenadine or any of its excipients.
Drug Interactions
Erythromycin and Ketoconazole
Concomitant administration with erythromycin or ketoconazole has been shown to result in increased plasma levels of fexofenadine, however, no differences in adverse effects were observed.
Aluminum and Magnesium Containing Antacids
Concomitant administration with aluminum and magnesium containing antacids reduces fexofenadine bioavailability. It is recommended to separate the administration of fexofenadine and antacids by about 2 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In overdose, dizziness, drowsiness, and dry mouth have been reported. Management should be symptomatic and supportive, including general measures to remove any unabsorbed drug and careful monitoring of the patient.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit outweighs the potential risk to the fetus. Fexofenadine is excreted in human breast milk; therefore, caution should be exercised when fexofenadine is administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture.
Availability
Available in pharmacies and drugstores
Approval Status
Approved
Patent Status
Off-patent
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Global Brand Names
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