Nafex
Generic Name
Fexofenadine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nafex 180 mg tablet | ৳ 9.50 | ৳ 95.00 |
Description
Overview of the medicine
Nafex 180 mg Tablet contains Fexofenadine Hydrochloride, a non-sedating antihistamine used to relieve allergy symptoms such as sneezing, runny nose, itchy eyes, and hives. It works by blocking histamine, a natural substance that the body produces during an allergic reaction.
Uses & Indications
Dosage
Adults
180 mg orally once daily for seasonal allergic rhinitis or chronic idiopathic urticaria.
Elderly
No specific dosage adjustment is generally required, but caution is advised in patients with renal impairment.
Renal_impairment
Dose adjustment may be necessary for severe renal impairment. Consult a physician.
How to Take
Take orally with water, with or without food. Do not take with fruit juice as it may reduce absorption. Do not exceed the recommended dose.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist. It competitively inhibits the binding of histamine to H1 receptors, thereby preventing the histamine-induced symptoms of allergic reactions. Unlike older antihistamines, it does not readily cross the blood-brain barrier, resulting in minimal to no sedative effects.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Primarily excreted unchanged in feces (80%) and urine (12%).
Half life
Approximately 11-15 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in approximately 1-3 hours.
Metabolism
Minimally metabolized; about 5% is metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any component of the formulation.
- Children under 6 years of age for 180mg strength.
Drug Interactions
Erythromycin or Ketoconazole
May increase fexofenadine plasma concentrations. Monitor for increased side effects.
Antacids containing aluminum or magnesium
May decrease the absorption of fexofenadine. Separate administration by approximately 2 hours.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include dizziness, drowsiness, and dry mouth. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered if recent ingestion. Hemodialysis does not effectively remove fexofenadine.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Small amounts may pass into breast milk; use with caution in breastfeeding mothers. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any component of the formulation.
- Children under 6 years of age for 180mg strength.
Drug Interactions
Erythromycin or Ketoconazole
May increase fexofenadine plasma concentrations. Monitor for increased side effects.
Antacids containing aluminum or magnesium
May decrease the absorption of fexofenadine. Separate administration by approximately 2 hours.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include dizziness, drowsiness, and dry mouth. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered if recent ingestion. Hemodialysis does not effectively remove fexofenadine.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Small amounts may pass into breast milk; use with caution in breastfeeding mothers. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved (DGDA, FDA)
Patent Status
Generic available (Patent expired)
Clinical Trials
Extensive clinical trials have demonstrated fexofenadine's efficacy and safety in treating seasonal allergic rhinitis and chronic idiopathic urticaria, with a favorable tolerability profile compared to first-generation antihistamines.
Lab Monitoring
- No routine laboratory monitoring is typically required.
Doctor Notes
- Advise patients to avoid concurrent use with antacids containing aluminum or magnesium.
- Counsel patients on the importance of avoiding fruit juices with this medication.
Patient Guidelines
- Do not take more than the prescribed dose.
- Avoid operating machinery or driving until you know how this medication affects you.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.
Driving Precautions
Fexofenadine is generally non-sedating, but individual responses vary. Exercise caution when driving or operating machinery until you are certain the medicine does not cause drowsiness or dizziness.
Lifestyle Advice
- Identify and avoid known allergens.
- Maintain a clean environment to reduce exposure to dust mites and pollen.
- Stay hydrated.
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