Nameton
Generic Name
Naproxen
Manufacturer
ABC Pharmaceuticals (Hypothetical)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nameton 750 mg tablet | ৳ 22.00 | ৳ 132.00 |
Description
Overview of the medicine
Naproxen is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever. It is effective in various conditions such as arthritis, menstrual pain, and other musculoskeletal aches.
Uses & Indications
Dosage
Adults
Usually 750-1500 mg daily, divided into two doses. Maximum 1500 mg/day.
Elderly
Lower doses should be initiated and used with caution due to increased risk of adverse effects.
Renal_impairment
Dose reduction or avoidance may be necessary; monitor renal function closely.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Do not crush or chew extended-release tablets.
Mechanism of Action
Naproxen works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are involved in the production of prostaglandins. Prostaglandins cause pain, inflammation, and fever.
Pharmacokinetics
Onset
Onset of action within 1-2 hours.
Excretion
Mainly excreted in the urine as unchanged drug and metabolites.
Half life
12-17 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver by demethylation.
Side Effects
Contraindications
- Hypersensitivity to Naproxen or other NSAIDs (e.g., aspirin-induced asthma, urticaria).
- Active peptic ulcer or gastrointestinal bleeding.
- Severe renal or hepatic impairment.
- Severe heart failure.
- Third trimester of pregnancy.
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
ACE Inhibitors/ARBs
May worsen renal function and reduce antihypertensive effect.
Diuretics (e.g., Furosemide)
Reduced diuretic effect.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptomatic and supportive treatment. Gastric lavage and activated charcoal may be considered. Closely monitor vital signs and renal function.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Consult a doctor before use during pregnancy or lactation.
Side Effects
Contraindications
- Hypersensitivity to Naproxen or other NSAIDs (e.g., aspirin-induced asthma, urticaria).
- Active peptic ulcer or gastrointestinal bleeding.
- Severe renal or hepatic impairment.
- Severe heart failure.
- Third trimester of pregnancy.
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
ACE Inhibitors/ARBs
May worsen renal function and reduce antihypertensive effect.
Diuretics (e.g., Furosemide)
Reduced diuretic effect.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptomatic and supportive treatment. Gastric lavage and activated charcoal may be considered. Closely monitor vital signs and renal function.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Consult a doctor before use during pregnancy or lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have been conducted on Naproxen to establish its efficacy and safety across various indications.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN)
- Liver function tests (e.g., ALT, AST)
- Complete Blood Count (CBC)
Doctor Notes
- Consider gastroprotection (e.g., PPI) for patients at high risk of GI complications, especially the elderly or those with a history of ulcers.
- Monitor renal function, blood pressure, and CBC periodically, especially during long-term therapy.
- Educate patients on the signs and symptoms of GI bleeding and cardiovascular events.
Patient Guidelines
- Take as directed by your doctor.
- Do not exceed the prescribed dose.
- Report any unusual side effects immediately.
- Do not use for prolonged periods without medical advice.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid alcohol consumption.
- Maintain adequate hydration.
- Avoid prolonged exposure to sunlight as it may cause photosensitivity.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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