Nandron
Generic Name
Nandrolone Decanoate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nandron 25 mg injection | ৳ 75.00 | N/A |
Description
Overview of the medicine
Nandron 25 mg Injection contains Nandrolone Decanoate, an anabolic androgenic steroid. It is used to promote weight gain, increase red blood cell production, and improve bone density in certain medical conditions, often when there is a deficiency or imbalance in natural steroid production or severe wasting diseases. It acts by promoting protein anabolism.
Uses & Indications
Dosage
Adults
Adults (anabolic effect): 25-50 mg by deep intramuscular injection every 3-4 weeks. For anemia of renal insufficiency: 50-100 mg intramuscularly once weekly.
Elderly
Lower doses may be considered; caution due to increased risk of adverse effects, especially prostate issues in males.
Renal_impairment
Use with caution. Dosage reduction may be necessary, especially in severe impairment. Close monitoring for fluid retention and electrolyte balance.
How to Take
Administer by deep intramuscular injection, preferably into the gluteal muscle. Do not administer intravenously.
Mechanism of Action
Nandrolone Decanoate binds to and activates androgen receptors in target tissues. This leads to increased protein synthesis, stimulation of erythropoiesis (red blood cell production), and increased bone density. It has a higher anabolic to androgenic ratio compared to testosterone, meaning it promotes more tissue building effects with relatively fewer masculinizing side effects.
Pharmacokinetics
Onset
Anabolic effects develop gradually over weeks.
Excretion
Primarily excreted in urine as metabolites, small amounts in feces.
Half life
Approximately 6-12 days (for the decanoate ester).
Absorption
Slowly absorbed from intramuscular injection site due to decanoate ester. Peak plasma levels reached within 24-48 hours.
Metabolism
Hydrolyzed to nandrolone, then metabolized in the liver, primarily via reduction and hydroxylation.
Side Effects
Contraindications
- Known or suspected prostate or male breast carcinoma
- Severe liver disease
- Nephrosis or the nephrotic phase of nephritis
- Hypercalcaemia (particularly in breast carcinoma)
- Pregnancy and breastfeeding
Drug Interactions
Corticosteroids
Increased risk of fluid retention.
Anticoagulants (e.g., Warfarin)
May enhance anticoagulant effects; dose adjustment may be necessary. Increased risk of bleeding.
Insulin and oral hypoglycemic agents
May decrease blood glucose levels; dose adjustment may be required.
Storage
Store below 30°C. Protect from light. Do not freeze. Keep in the original package.
Overdose
Overdose may lead to increased side effects, including virilization in females, fluid retention, and liver issues. Treatment is symptomatic and supportive. Discontinue the drug and manage symptoms as appropriate.
Pregnancy & Lactation
Nandrolone Decanoate is contraindicated during pregnancy due to the risk of fetal masculinization. It should not be used during breastfeeding as it may pass into breast milk and cause adverse effects in the infant.
Side Effects
Contraindications
- Known or suspected prostate or male breast carcinoma
- Severe liver disease
- Nephrosis or the nephrotic phase of nephritis
- Hypercalcaemia (particularly in breast carcinoma)
- Pregnancy and breastfeeding
Drug Interactions
Corticosteroids
Increased risk of fluid retention.
Anticoagulants (e.g., Warfarin)
May enhance anticoagulant effects; dose adjustment may be necessary. Increased risk of bleeding.
Insulin and oral hypoglycemic agents
May decrease blood glucose levels; dose adjustment may be required.
Storage
Store below 30°C. Protect from light. Do not freeze. Keep in the original package.
Overdose
Overdose may lead to increased side effects, including virilization in females, fluid retention, and liver issues. Treatment is symptomatic and supportive. Discontinue the drug and manage symptoms as appropriate.
Pregnancy & Lactation
Nandrolone Decanoate is contraindicated during pregnancy due to the risk of fetal masculinization. It should not be used during breastfeeding as it may pass into breast milk and cause adverse effects in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, refer to packaging for exact date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic, patent expired
Clinical Trials
Nandrolone Decanoate has been extensively studied in various clinical trials for its indicated uses since its introduction. Current research focuses on long-term safety, specific patient populations, and comparison with newer therapies.
Lab Monitoring
- Liver function tests (LFTs)
- Lipid profile
- Hemoglobin and Hematocrit
- Serum electrolytes
- Prostate-specific antigen (PSA) in males
Doctor Notes
- Strictly adhere to indications and dosage guidelines.
- Monitor liver function, lipid profile, and hematocrit regularly.
- Educate patients on potential side effects, especially virilization and cardiovascular risks.
- Assess for potential abuse and dependence.
- Consider prostate examination and PSA levels in male patients, especially elderly.
Patient Guidelines
- Do not exceed the prescribed dose or duration of treatment.
- Report any unusual side effects, especially virilization signs in females, to your doctor.
- Regular monitoring by a doctor is crucial during treatment.
- This medicine should only be administered by a healthcare professional.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, contact your doctor or nurse for advice. Do not double the dose to compensate for a missed one.
Driving Precautions
Nandrolone Decanoate is not generally known to impair the ability to drive or operate machinery. However, if you experience mood changes or other side effects affecting concentration, avoid such activities.
Lifestyle Advice
- Maintain a balanced diet and regular exercise routine as advised by your doctor to support the therapeutic effects.
- Avoid alcohol consumption as it may increase the risk of liver side effects.
- Do not use this medicine for non-medical purposes (e.g., athletic performance enhancement) due to severe health risks.
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