Oral administration. Tablets should be swallowed whole with a glass of water, preferably with food or milk to minimize gastrointestinal upset. Do not crush or chew enteric-coated tablets.

Naproxen works by inhibiting the activity of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. This inhibition reduces the production of prostaglandins, which are chemicals in the body that contribute to pain, inflammation, and fever.

• •Hypersensitivity to naproxen, aspirin, or other NSAIDs (may cause asthma, urticaria, or allergic-type reactions).
• •Active gastrointestinal bleeding or peptic ulcer disease.
• •Severe renal or hepatic impairment.
• •Severe heart failure.
• •Third trimester of pregnancy.
• •Coronary artery bypass graft (CABG) surgery (peri-operative pain).

Store at room temperature (20-25°C or 68-77°F). Protect from moisture and light. Keep out of reach of children.

Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, lethargy, dizziness, and sometimes GI bleeding. Rare symptoms include hypertension, acute renal failure, respiratory depression, and coma. Management is supportive and symptomatic; gastric lavage or activated charcoal may be considered if ingestion is recent.

Pregnancy: Category C in first two trimesters, Category D in third trimester. Avoid in the third trimester due to risk of premature closure of the fetal ductus arteriosus. Use only if potential benefit justifies the potential risk to the fetus in first/second trimesters. Lactation: Naproxen is excreted in human milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.