Take orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a full glass of water. Do not crush, chew, or break extended-release or enteric-coated tablets.

Naproxen works by inhibiting cyclooxygenase (COX) enzymes, specifically both COX-1 and COX-2. This inhibition leads to a reduction in prostaglandin synthesis, which are mediators of pain, inflammation, and fever.

• •Hypersensitivity to naproxen or any component of the formulation
• •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
• •Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
• •Severe uncontrolled heart failure
• •Severe renal or hepatic impairment
• •Active gastrointestinal bleeding or peptic ulcer disease
• •Third trimester of pregnancy

Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.

Symptoms of overdose may include drowsiness, dizziness, nausea, vomiting, epigastric pain, and rarely, gastrointestinal bleeding. More severe symptoms such as acute renal failure, respiratory depression, and coma may occur. Management involves symptomatic and supportive care. Gastric lavage and/or activated charcoal may be considered within 1 hour of ingestion.

Pregnancy Category C (first and second trimester), Category D (third trimester). Avoid in the third trimester due to the risk of premature closure of the fetal ductus arteriosus. Use with caution in the first and second trimesters only if the potential benefit justifies the potential risk to the fetus. Naproxen is excreted in breast milk; therefore, it should be used with caution in nursing mothers.