Naproxen
Generic Name
Naproxen 500 mg Tablet
Manufacturer
Various Manufacturers
Country
Global
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| napoxen 500 mg tablet | ৳ 7.00 | N/A |
Description
Overview of the medicine
Naproxen is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of mild to moderate pain, fever, inflammation, and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, tendinitis, bursitis, and primary dysmenorrhea. It works by reducing hormones that cause inflammation and pain in the body.
Uses & Indications
Dosage
Adults
For rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis: 250 mg to 500 mg orally twice daily. For acute gout: 750 mg orally, followed by 250 mg every 8 hours until the attack subsides. For mild to moderate pain, dysmenorrhea, tendinitis, and bursitis: 500 mg orally, followed by 250 mg every 6-8 hours as needed.
Elderly
Use the lowest effective dose for the shortest duration. Monitor for adverse effects, especially gastrointestinal and renal.
Renal_impairment
Not recommended for patients with advanced renal disease. For others, reduce dosage and monitor renal function closely.
How to Take
Take orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a full glass of water. Do not crush, chew, or break extended-release or enteric-coated tablets.
Mechanism of Action
Naproxen works by inhibiting cyclooxygenase (COX) enzymes, specifically both COX-1 and COX-2. This inhibition leads to a reduction in prostaglandin synthesis, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Pain relief may begin within 1-2 hours; anti-inflammatory effects may take up to 2 weeks.
Excretion
Approximately 95% of naproxen and its metabolites are excreted in the urine, with a small amount in feces.
Half life
Approximately 12-17 hours, allowing for twice-daily dosing.
Absorption
Rapid and complete absorption from the gastrointestinal tract; food may delay but not affect the extent of absorption.
Metabolism
Extensively metabolized in the liver by CYP2C9 to 6-O-desmethylnaproxen, which is then glucuronidated.
Side Effects
Contraindications
- Hypersensitivity to naproxen or any component of the formulation
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
- Severe uncontrolled heart failure
- Severe renal or hepatic impairment
- Active gastrointestinal bleeding or peptic ulcer disease
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium concentrations, leading to toxicity.
Methotrexate
Increased plasma methotrexate concentrations, enhancing toxicity.
ACE Inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Other NSAIDs or Aspirin
Increased risk of gastrointestinal adverse effects.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Selective Serotonin Reuptake Inhibitors (SSRIs)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, nausea, vomiting, epigastric pain, and rarely, gastrointestinal bleeding. More severe symptoms such as acute renal failure, respiratory depression, and coma may occur. Management involves symptomatic and supportive care. Gastric lavage and/or activated charcoal may be considered within 1 hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C (first and second trimester), Category D (third trimester). Avoid in the third trimester due to the risk of premature closure of the fetal ductus arteriosus. Use with caution in the first and second trimesters only if the potential benefit justifies the potential risk to the fetus. Naproxen is excreted in breast milk; therefore, it should be used with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to naproxen or any component of the formulation
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
- Severe uncontrolled heart failure
- Severe renal or hepatic impairment
- Active gastrointestinal bleeding or peptic ulcer disease
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium concentrations, leading to toxicity.
Methotrexate
Increased plasma methotrexate concentrations, enhancing toxicity.
ACE Inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Other NSAIDs or Aspirin
Increased risk of gastrointestinal adverse effects.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Selective Serotonin Reuptake Inhibitors (SSRIs)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, nausea, vomiting, epigastric pain, and rarely, gastrointestinal bleeding. More severe symptoms such as acute renal failure, respiratory depression, and coma may occur. Management involves symptomatic and supportive care. Gastric lavage and/or activated charcoal may be considered within 1 hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C (first and second trimester), Category D (third trimester). Avoid in the third trimester due to the risk of premature closure of the fetal ductus arteriosus. Use with caution in the first and second trimesters only if the potential benefit justifies the potential risk to the fetus. Naproxen is excreted in breast milk; therefore, it should be used with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from the date of manufacture, depending on the manufacturer and specific formulation.
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established naproxen's efficacy and safety for various pain and inflammatory conditions. Ongoing post-marketing surveillance and studies continue to refine its risk-benefit profile.
Lab Monitoring
- Complete Blood Count (CBC) with differential, especially with long-term use
- Renal function tests (serum creatinine, BUN) periodically, especially in elderly or those with impaired renal function
- Liver function tests (ALT, AST) periodically
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Carefully assess cardiovascular and gastrointestinal risk factors before prescribing, especially for elderly patients or those with a history of GI events.
- Monitor renal function, liver enzymes, and blood pressure periodically during long-term therapy.
- Advise patients on signs and symptoms of serious adverse reactions and when to seek medical attention.
Patient Guidelines
- Take with food or milk to minimize stomach upset.
- Do not exceed the prescribed dose or duration of treatment.
- Report any signs of gastrointestinal bleeding (black, tarry stools; vomiting blood) or cardiovascular symptoms (chest pain, shortness of breath) immediately.
- Avoid alcohol while taking this medicine.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Naproxen may cause dizziness, drowsiness, or visual disturbances in some patients. Patients should be cautioned about engaging in activities requiring mental alertness, such as driving or operating machinery, until they know how the drug affects them.
Lifestyle Advice
- Maintain a healthy diet and stay hydrated.
- Limit or avoid alcohol to reduce the risk of stomach irritation and bleeding.
- Engage in regular, moderate exercise suitable for your condition.
- If pain persists, consult your doctor for further evaluation.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Naproxen Brand
Other medicines available under the same brand name
