Napro
Generic Name
Naproxen
Manufacturer
Reputable pharmaceutical companies (varies by region)
Country
Bangladesh (for local production/availability)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| napro 250 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Naproxen 250 mg tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever. It is commonly prescribed for conditions like arthritis, menstrual pain, and acute injuries.
Uses & Indications
Dosage
Adults
For mild to moderate pain, dysmenorrhea: Initially 500 mg, then 250 mg every 6-8 hours as needed. Maximum initial dose is 1250 mg/day, then 1000 mg/day. For chronic conditions (e.g., arthritis): 250-500 mg twice daily.
Elderly
Use the lowest effective dose for the shortest duration. Monitor for renal and gastrointestinal adverse effects.
Renal_impairment
Use with caution and at reduced doses. Avoid in severe renal impairment (creatinine clearance < 30 mL/min).
How to Take
Take the tablet orally with a full glass of water. It can be taken with food or milk to minimize gastrointestinal upset.
Mechanism of Action
Naproxen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever. By blocking their production, naproxen reduces these symptoms.
Pharmacokinetics
Onset
Approximately 1 hour for pain relief.
Excretion
Mainly excreted in the urine (95%), as naproxen, 6-O-desmethylnaproxen, or their conjugates.
Half life
12-17 hours.
Absorption
Well absorbed from the gastrointestinal tract; peak plasma concentrations occur within 2-4 hours.
Metabolism
Primarily hepatic via demethylation and conjugation.
Side Effects
Contraindications
- •Hypersensitivity to naproxen, aspirin, or other NSAIDs
- •History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
- •Active or recurrent peptic ulcer/hemorrhage
- •Severe heart failure
- •Severe renal impairment
- •Third trimester of pregnancy
- •Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Drug Interactions
Lithium
Increased plasma lithium levels.
SSRIs/SNRIs
Increased risk of gastrointestinal bleeding.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration/bleeding.
ACE inhibitors/ARBs
Reduced antihypertensive effect; increased risk of renal impairment.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects; increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, heartburn, nausea, vomiting, epigastric pain, lethargy. Severe overdose can lead to gastrointestinal bleeding, acute renal failure, coma. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Avoid in the third trimester due to potential fetal harm (premature closure of ductus arteriosus). Use with caution during lactation; small amounts may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture. Check the expiry date on the packaging.
Availability
Available in pharmacies nationwide
Approval Status
Approved (DGDA, FDA and other regulatory bodies)
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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