Naprotec
Generic Name
Naproxen
Manufacturer
Square Pharmaceuticals PLC
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| naprotec 500 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Naprotec 500 mg Tablet contains Naproxen, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and stiffness caused by various conditions such as arthritis, gout, and menstrual cramps. It works by blocking the body's production of certain natural substances that cause inflammation.
Uses & Indications
Dosage
Adults
Typically 250 mg to 500 mg twice daily. Maximum recommended daily dose is 1000 mg.
Elderly
Lower doses should be considered; careful monitoring for adverse effects is recommended.
Renal_impairment
Dose reduction may be necessary. Not recommended for patients with severe renal impairment (creatinine clearance <30 mL/min).
How to Take
Take orally, preferably with food or milk, to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Naproxen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. This leads to anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics
Onset
Pain relief typically begins within 1 hour; anti-inflammatory effects may take several days.
Excretion
Primarily excreted in the urine (approximately 95%) as unchanged drug, 6-O-desmethylnaproxen, and their conjugates; a small amount is excreted in feces.
Half life
Approximately 12-17 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract; peak plasma concentrations reached in 2-4 hours.
Metabolism
Extensively metabolized in the liver via demethylation and conjugation to 6-O-desmethylnaproxen and its conjugates.
Side Effects
Contraindications
- •Hypersensitivity to Naproxen or other NSAIDs (e.g., aspirin)
- •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- •Active or recurrent peptic ulcer/hemorrhage
- •Severe heart failure
- •Severe renal impairment
- •Severe hepatic impairment
- •Third trimester of pregnancy
- •Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels, potentially leading to toxicity.
Methotrexate
Increased plasma methotrexate levels, potentially leading to toxicity.
Cyclosporine, Tacrolimus
Increased risk of nephrotoxicity.
Diuretics and ACE Inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Selective Serotonin Reuptake Inhibitors (SSRIs)
Increased risk of gastrointestinal bleeding.
Antiplatelet agents (e.g., Aspirin, Clopidogrel)
Increased risk of gastrointestinal bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves gastric lavage, activated charcoal, and symptomatic and supportive therapy. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Avoid in late pregnancy due to potential for premature closure of ductus arteriosus and effects on labor. Use with caution during lactation; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies globally
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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