Napsod
Generic Name
Naproxen
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| napsod 275 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Napsod 275 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used for pain relief, reduction of inflammation, and fever. It is commonly prescribed for conditions like arthritis, menstrual cramps, and musculoskeletal pain.
Uses & Indications
Dosage
Adults
For mild to moderate pain, initial dose 275 mg or 550 mg, then 275 mg every 6-8 hours or 550 mg every 12 hours as needed. Max 1375 mg/day.
Elderly
Use the lowest effective dose for the shortest duration. Monitor for renal and gastrointestinal effects.
Renal_impairment
Dosage adjustment may be necessary. Not recommended for severe renal impairment (creatinine clearance <30 mL/min).
How to Take
Orally, with food or milk to minimize gastrointestinal upset. Swallow whole with a glass of water.
Mechanism of Action
Naproxen works by inhibiting the production of prostaglandins, which are chemicals in the body that cause inflammation, pain, and fever. It primarily inhibits cyclooxygenase (COX-1 and COX-2) enzymes.
Pharmacokinetics
Onset
Pain relief within 1 hour; anti-inflammatory effects may take longer.
Excretion
Primarily excreted in the urine (about 95% as naproxen, 6-O-desmethylnaproxen, or their conjugates).
Half life
Approximately 12-17 hours.
Absorption
Well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 2-4 hours.
Metabolism
Extensively metabolized in the liver to 6-O-desmethylnaproxen and other metabolites.
Side Effects
Contraindications
- Hypersensitivity to naproxen or other NSAIDs
- Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal, hepatic, or heart failure
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery
Drug Interactions
Lithium
Increased lithium plasma levels and toxicity.
Methotrexate
Increased methotrexate toxicity.
Other NSAIDs
Increased risk of adverse effects.
ACE inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Antiplatelet agents (e.g., Aspirin)
Increased risk of bleeding and GI ulceration.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, heartburn, indigestion, nausea, vomiting. Severe overdose may lead to kidney failure, liver damage, and gastrointestinal bleeding. Management involves symptomatic and supportive measures. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy category C in first and second trimesters, D in third trimester. Avoid in late pregnancy due to risk of premature closure of ductus arteriosus. Use with caution in breastfeeding; small amounts pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to naproxen or other NSAIDs
- Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal, hepatic, or heart failure
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery
Drug Interactions
Lithium
Increased lithium plasma levels and toxicity.
Methotrexate
Increased methotrexate toxicity.
Other NSAIDs
Increased risk of adverse effects.
ACE inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Antiplatelet agents (e.g., Aspirin)
Increased risk of bleeding and GI ulceration.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, heartburn, indigestion, nausea, vomiting. Severe overdose may lead to kidney failure, liver damage, and gastrointestinal bleeding. Management involves symptomatic and supportive measures. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy category C in first and second trimesters, D in third trimester. Avoid in late pregnancy due to risk of premature closure of ductus arteriosus. Use with caution in breastfeeding; small amounts pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support the efficacy and safety of naproxen for various inflammatory and pain conditions. Ongoing research focuses on long-term cardiovascular and gastrointestinal safety profiles.
Lab Monitoring
- Complete Blood Count (CBC)
- Renal function tests (Creatinine, BUN)
- Liver function tests (ALT, AST)
- Stool for occult blood (long-term use)
Doctor Notes
- Caution in patients with a history of GI disorders, hypertension, or heart failure.
- Consider co-prescription of a proton pump inhibitor for high-risk patients on long-term therapy.
- Monitor renal function, blood pressure, and CBC periodically.
Patient Guidelines
- Take with food or milk to reduce stomach upset.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Avoid alcohol while taking this medicine.
- Report any signs of stomach bleeding (black stools, vomiting blood) immediately.
- Avoid prolonged exposure to sunlight as it may increase photosensitivity.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a healthy diet.
- Stay hydrated.
- Engage in moderate physical activity (if appropriate for your condition).
- Avoid smoking.
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